Tricomponent Amphiphilic Poly(oligo(ethylene glycol) methacrylate) Brush-Grafted Poly(lactic acid): Synthesis, Nanoparticle Formation, and In Vitro Uptake and Release of Hydrophobic Dyes

被引：12

作者：

Kalelkar, Pranav P. ^{[1
]}

Collard, David M. ^{[1
]}

机构：

[1] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA

来源：

MACROMOLECULES | 2020年 / 53卷 / 11期

关键词：

RING-OPENING POLYMERIZATION; DRUG-RELEASE; CLICK CHEMISTRY; POLY(ETHYLENE GLYCOL); TRIBLOCK COPOLYMERS; POLYLACTIDE; PLA; DELIVERY; PEG; BLOCK;

D O I：

10.1021/acs.macromol.9b02467

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Tricomponent amphiphilic brush-grafted copolymers of poly(lactic acid)-graft-poly(oligo(ethylene glycol) methacrylate) (PLA-g-POEGMA) were prepared by atom-transfer radical polymerization (ATRP) of oligo(ethylene glycol) methacrylate (OEGMA) macromer using brominated poly(lactic acid) (Br-PLA) as a multisite macroinitiator. Br-PLA was prepared by free radical bromination of poly(lactic acid) (PLA) with N-bromosuccinimide (NBS). The amphiphilic copolymer, PLA-g-POEGMA, self-assembled to form sub-100 nm nanoparticles in aqueous solution. We report the uptake and release of hydrophobic dyes by the nanoparticles in buffer and in the presence of serum proteins and the low toxicity toward mammalian cells.

引用

页码：4274 / 4283

页数：10

共 63 条

[11] Single-Chain Polymeric Nanocarriers: A Platform for Determining Structure-Function Correlations in the Delivery of Molecular Cargo [J].

Chan, Doreen ;

Yu, Anthony C. ;

Appel, Eric A. .

BIOMACROMOLECULES, 2017, 18 (04) :1434-1439

[12] Poly(ethylene glycol)-block-cationic polylactide nanocomplexes of differing charge density for gene delivery [J].

Chen, Chih-Kuang ;

Jones, Charles H. ;

Mistriotis, Panagiotis ;

Yu, Yun ;

Ma, Xiaoni ;

Ravikrishnan, Anitha ;

Jiang, Ming ;

Andreadis, Stelios T. ;

Pfeifer, Blaine A. ;

Cheng, Chong .

BIOMATERIALS, 2013, 34 (37) :9688-9699

[13] New bio-renewable polyester with rich side amino groups from L-lysine via controlled ring-opening polymerization [J].

Chen, Xiaoyu ;

Lai, Haiwang ;

Xiao, Chunsheng ;

Tian, Huayu ;

Chen, Xuesi ;

Tao, Youhua ;

Wang, Xianhong .

POLYMER CHEMISTRY, 2014, 5 (22) :6495-6502

[14] Self-assembly of well-defined triblock copolymers based on poly(lactic acid) and poly(oligo(ethylene glycol) methyl ether methacrylate) prepared by ATRP [J].

Coumes, F. ;

Beaute, L. ;

Domurado, D. ;

Li, S. ;

Lecommandoux, S. ;

Coudane, J. ;

Darcos, V. .

RSC ADVANCES, 2016, 6 (58) :53370-53377

[15] Synthesis and ring-opening polymerisation of a new alkyne-functionalised glycolide towards biocompatible amphiphilic graft copolymers [J].

Coumes, Fanny ;

Darcos, Vincent ;

Domurado, Dominique ;

Li, Suming ;

Coudane, Jean .

POLYMER CHEMISTRY, 2013, 4 (13) :3705-3713

[16] Controlled ring-opening polymerization of lactide and glycolide [J].

Dechy-Cabaret, O ;

Martin-Vaca, B ;

Bourissou, D .

CHEMICAL REVIEWS, 2004, 104 (12) :6147-6176

[17] Role of physicochemical properties of coating ligands in receptor-mediated endocytosis of nanoparticles [J].

Ding, Hong-ming ;

Ma, Yu-qiang .

BIOMATERIALS, 2012, 33 (23) :5798-5802

[18] Template-Assisted Enzymatic Synthesis of Oligopeptides from a Polylactide Chain [J].

Fagerland, Jenny ;

Pappalardo, Daniela ;

Schmidt, Bjorn ;

Syren, Per-Olof ;

Finne-Wistrand, Anna .

BIOMACROMOLECULES, 2017, 18 (12) :4271-4280

[19] Redox-Responsive Disulfide Cross-Linked PLA-PEG Nanoparticles [J].

Fuoco, Tiziana ;

Pappalardo, Daniela ;

Finne-Wistrand, Anna .

MACROMOLECULES, 2017, 50 (18) :7052-7061

[20] A Route to Aliphatic Poly(ester)s with Thiol Pendant Groups: From Monomer Design to Editable Porous Scaffolds [J].

Fuoco, Tiziana ;

Finne-Wistrand, Anna ;

Pappalardo, Daniela .

BIOMACROMOLECULES, 2016, 17 (04) :1383-1394

← 1 2 3 4 5 6 7 →