Tricomponent Amphiphilic Poly(oligo(ethylene glycol) methacrylate) Brush-Grafted Poly(lactic acid): Synthesis, Nanoparticle Formation, and In Vitro Uptake and Release of Hydrophobic Dyes

被引：12

作者：

Kalelkar, Pranav P. ^{[1
]}

Collard, David M. ^{[1
]}

机构：

[1] Georgia Inst Technol, Sch Chem & Biochem, Atlanta, GA 30332 USA

来源：

MACROMOLECULES | 2020年 / 53卷 / 11期

关键词：

RING-OPENING POLYMERIZATION; DRUG-RELEASE; CLICK CHEMISTRY; POLY(ETHYLENE GLYCOL); TRIBLOCK COPOLYMERS; POLYLACTIDE; PLA; DELIVERY; PEG; BLOCK;

D O I：

10.1021/acs.macromol.9b02467

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

Tricomponent amphiphilic brush-grafted copolymers of poly(lactic acid)-graft-poly(oligo(ethylene glycol) methacrylate) (PLA-g-POEGMA) were prepared by atom-transfer radical polymerization (ATRP) of oligo(ethylene glycol) methacrylate (OEGMA) macromer using brominated poly(lactic acid) (Br-PLA) as a multisite macroinitiator. Br-PLA was prepared by free radical bromination of poly(lactic acid) (PLA) with N-bromosuccinimide (NBS). The amphiphilic copolymer, PLA-g-POEGMA, self-assembled to form sub-100 nm nanoparticles in aqueous solution. We report the uptake and release of hydrophobic dyes by the nanoparticles in buffer and in the presence of serum proteins and the low toxicity toward mammalian cells.

引用

页码：4274 / 4283

页数：10

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