Effects of antiflammins on transglutaminase and phospholipase A2 activation by transglutaminase

被引：14
作者：
Moreno, JJ [1 ]
机构：
[1] Univ Barcelona, Fac Pharm, Dept Physiol, Barcelona, Spain
来源：
INTERNATIONAL IMMUNOPHARMACOLOGY | 2006年 / 6卷 / 02期
关键词：
anti-inflammatory drugs; lipocortin; uteroglobin; arachidonic acid; eicosanoids;
D O I：
10.1016/j.intimp.2005.08.001
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Two anti-inflammatory peptides, named antiflammins (AFs), corresponding to a region with high amino acid similarity between lipocortin-1 and uteroglobin were tested for their ability to inhibit transglutaminase (TG) and low-molecular-mass phospholipase A(2) (PLA(2)) Porcine pancreatic PLA2 activity and guinea pig hepatic TG activity were determined by arachidonyl release from arachidonyl-phosphatidylcholine and by the incorporation of putrescine into succinylated casein, respectively. AFs inhibited TG activity but did not affect PLA(2) activity. Moreover, porcine pancreatic PLA(2) was activated by TG and AFs decreased porcine pancreatic PLA(2) activation induced by TG. Taken together, our results support the hypothesis that the anti-inflammatory effects of AFs are, at least in part, due to the action of AFs on TG activity. (c) 2005 Elsevier B.V. All rights reserved.
引用
收藏
页码：300 / 303
页数：4
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