Peroxiredoxin I deficiency attenuates phagocytic capacity of macrophage in clearance of the red blood cells damaged by oxidative stress

被引：11
作者：
Han, Ying-Hao [1 ,9 ]
Kwon, Taeho [1 ,8 ]
Kim, Sun-Uk [1 ,2 ]
Ha, Hye-Lin [1 ]
Lee, Tae-Hoon [1 ,3 ]
Kim, Jin-Man [4 ]
Jo, Eun-Kyeong [5 ]
Kim, Bo Yeon [6 ,7 ]
Yoon, Do Young [8 ]
Yu, Dae-Yeul [1 ]
机构：
[1] KRIBB, Aging Res Ctr, Taejon 305806, South Korea
[2] KRIBB, Natl Primate Res Ctr Korea, Taejon 305806, South Korea
[3] Chonnam Natl Univ, Dent Sci Res Inst, Dept Biochem, Kwangju 500757, South Korea
[4] Chungnam Natl Univ, Dept Pathol, Coll Med, Taejon 301747, South Korea
[5] Chungnam Natl Univ, Dept Microbiol, Coll Med, Taejon 301747, South Korea
[6] Korea Res Inst Biosci & Biotechnol, Chem Biol Res Ctr, Cheongwon 363883, South Korea
[7] Korea Res Inst Biosci & Biotechnol, World Class Inst, Cheongwon 363883, South Korea
[8] Konkuk Univ, Bio Mol Informat Ctr, Dept Biosci & Biotechnol, Seoul 143701, South Korea
[9] Heilongjiang Bayi Agr Univ DaQing, Coll Life Sci & Technol, Daqing 163319, Heilongjiang Pr, Peoples R China
来源：
BMB REPORTS | 2012年 / 45卷 / 10期
基金：
新加坡国家研究基金会;
关键词：
Heinz body; Hemolytic anemia; Macrophage; Peroxiredoxin; Phagocytosis; HYDROGEN-PEROXIDE; MAMMALIAN PEROXIREDOXIN; PRDX1; MICE; ERYTHROCYTE; ACTIVATION; PROTEINS; ISOFORMS; DEATH;
D O I：
10.5483/BMBRep.2012.45.10.082
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The role of peroxiredoxin (Prx) I as an erythrocyte antioxidant defense in red blood cells (RBCs) is controversial. Here we investigated the function of Prx I by using Prx I-/- and Prx I/II-/- mice. Prx I-/- mice exhibited a normal blood profile. However, Prx I-/- mice showed more significantly increased Heinz body formation as compared with Prx II-/- mice. The clearance rate of Heinz body-containing RBCs in Prx I-/- mice decreased significantly through the treatment of aniline hydrochloride (AH) compared with wild-type mice. Prx I deficiency decreased the phagocytic capacity of macrophage in clearing Heinz body-containing RBCs. Our data demonstrate that Prx I deficiency did not cause hemolytic anemia, but showed that further increased hemolytic anemia symptoms in Prx II-/- mice by attenuating phagocytic capacity of macrophage in oxidative stress damaged RBCs, suggesting a novel role of Pi, I in phagocytosis of macrophage. [BMB Reports 2012; 45(10): 560-564]
引用
收藏
页码：560 / 564
页数：5
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