Deubiquitinases in cancer

被引：55
作者：
Wei, Rongbin [1 ]
Liu, Xiaodong [2 ]
Yu, Weixin [3 ]
Yang, Tianshu [1 ]
Cai, Wenping [1 ]
Liu, Junjun [1 ]
Huang, Xiao [1 ]
Xu, Guo-Tong [1 ]
Zhao, Shouliang [3 ]
Yang, Jianhua [1 ]
Liu, Shangfeng [3 ]
机构：
[1] Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Dept Ophthalmol, Shanghai 200072, Peoples R China
[2] Fudan Univ, Huashan Hosp, Dept Neurosurg, Shanghai 200040, Peoples R China
[3] Fudan Univ, Huashan Hosp, Dept Stomatol, Shanghai 200040, Peoples R China
来源：
ONCOTARGET | 2015年 / 6卷 / 15期
基金：
上海市自然科学基金; 中国国家自然科学基金;
关键词：
deubiquitinases; cancer; ubiquitylation; inhibitor; UBIQUITIN-SPECIFIC PROTEASE; SMALL-MOLECULE INHIBITOR; ANTIRHEUMATIC AGENT AURANOFIN; TUMOR-SUPPRESSOR; TGF-BETA; DEUBIQUITYLATING ENZYME; NEGATIVE REGULATION; COLORECTAL-CANCER; MULTIPLE-MYELOMA; OVER-EXPRESSION;
D O I：
10.18632/oncotarget.3671
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Deubiquitinases are deubiquitinating enzymes (DUBs), which remove ubiquitin from proteins, thus regulating their proteasomal degradation, localization and activity. Here, we discuss DUBs as anti-cancer drug targets.
引用
收藏
页码：12872 / 12889
页数：18
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