Association between a functional insertion/deletion polymorphism in IL1A gene and risk of papillary thyroid carcinoma

被引：20

作者：

Gao, Linbo ^{[1
,2
]}

Zhu, Xinxin ^{[3
]}

Li, Zhihui ^{[3
]}

Li, Lijuan ^{[1
,4
]}

Wang, Tao ^{[1
,2
]}

Hu, Huaizhong ^{[1
,2
]}

Guo, Wanli ^{[1
,2
]}

Chen, Peng ^{[4
]}

Zhu, Jingqiang ^{[3
]}

Zhang, Lin ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Inst Women & Childrens Hlth, West China Univ Hosp 2, Lab Mol & Translat Med, Chengdu 610041, Sichuan, Peoples R China

[2] Minist Educ, Key Lab Obstet & Gynecol & Pediat Dis & Birth Def, Chengdu 610041, Sichuan, Peoples R China

[3] Sichuan Univ, West China Hosp, Dept Thyroid & Breast Surg, Chengdu 610041, Sichuan, Peoples R China

[4] Sichuan Univ, West China Sch Preclin & Forens Med, Dept Forens Biol, Chengdu 610041, Sichuan, Peoples R China

来源：

TUMOR BIOLOGY | 2014年 / 35卷 / 04期

基金：

中国国家自然科学基金;

关键词：

miRNA; Polymorphism; IL1A; Insertion/deletion; Papillary thyroid carcinoma; INCREASING INCIDENCE; UNITED-STATES; CELL-LINE; CANCER; INTERLEUKIN-1-ALPHA; MICRORNAS; SITE; INFLAMMATION; MIR-122; SNP;

D O I：

10.1007/s13277-013-1512-6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The aim of this study was to evaluate whether an insertion/deletion polymorphism (rs3783553) locating in the miR-122 target gene IL1A 3' untranslated region was related to the risk of papillary thyroid carcinoma (PTC). Genomic DNA was extracted from peripheral venous blood of 273 patients with PTC and 509 controls. The IL1A rs3783553 polymorphism was genotyped by using a polymerase chain reaction assay. No significant difference of the distribution of the IL1A rs3783553 polymorphism was observed between PTC patients and controls. However, patients carrying the IL1A rs3783553 ins/ins genotype and ins allele had significantly decreased risks for developing T3 and T4 when compared with patients carrying the IL1A rs3783553 del/del genotype and del allele (ins/ins vs. del/del: OR = 0.22, 95 % confidence interval (CI), 0.09-0.54; ins vs. del: OR = 0.58, 95 % CI, 0.41-0.83, respectively). These results suggest that the rs3783553 polymorphism may be used as a genetic marker to predict the size/extension of PTC.

引用

页码：3861 / 3865

页数：5

共 28 条

[1] Inflammation and cancer: How hot is the link? [J].