BCX4161, An Oral Kallikrein Inhibitor: Safety and Pharmacokinetic Results Of a Phase 1 Study In Healthy Volunteers

被引：1
|
作者：
Collis, Phil [1 ]
Cornpropst, Melanie [1 ]
Collier, Jo [2 ]
Sheridan, William [1 ]
机构：
[1] BioCryst Pharmaceut, Durham, NC USA
[2] Quotient Clin, Nottingham, England
来源：
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2014年 / 133卷 / 02期
关键词：
D O I：
10.1016/j.jaci.2013.12.162
中图分类号：
R392 [医学免疫学];
学科分类号：
100102 ;
摘要：
138
引用
收藏
页码：AB39 / AB39
页数：1
相关论文
共 50 条
  • [11] BCX9930, an Oral Factor D Inhibitor, for the Potential Treatment of Alternative Pathway Mediated Diseases: Interim Results of a Phase 1 Study in Healthy Subjects
    Davidson, Matthew
    Mathis, Amanda
    Mair, Stuart
    Gesty-Palmer, Diane
    Cornpropst, Melanie
    Sheridan, William P.
    Chen, Xilin
    Reynolds, David
    Parker, Cynthia
    Babu, Yarlagadda S.
    BLOOD, 2020, 136
  • [12] The Pharmacokinetics, Pharmacodynamics, and Safety of Baricitinib, an Oral JAK 1/2 Inhibitor, in Healthy Volunteers
    Shi, Jack G.
    Chen, Xuejun
    Lee, Fiona
    Emm, Thomas
    Scherle, Peggy A.
    Lo, Yvonne
    Punwani, Naresh
    Williams, William V.
    Yeleswaram, Swamy
    JOURNAL OF CLINICAL PHARMACOLOGY, 2014, 54 (12): : 1354 - 1361
  • [13] Results of a safety, tolerability and pharmacokinetic phase I study of VCH-916, a novel polymerase inhibitor for HCV, following single ascending doses in healthy volunteers
    Proulx, L.
    Bourgault, B.
    Chauret, N.
    Larouche, R.
    Tanguay, M.
    Thibert, R.
    JOURNAL OF HEPATOLOGY, 2008, 48 : S320 - S321
  • [14] Pharmacokinetic interaction of the oral renin inhibitor aliskiren with hydrochlorothiazide in healthy volunteers.
    Dieterich, H
    Kemp, C
    Vaidyanathan, S
    Yeh, C
    CLINICAL PHARMACOLOGY & THERAPEUTICS, 2006, 79 (02) : P12 - P12
  • [15] A PHASE 1 STUDY IN HEALTHY VOLUNTEERS EXPLORING THE SAFETY, PHARMACOKINETICS AND PHARMACODYNAMICS OF ATI-450: A NOVEL ORAL MK2 INHIBITOR
    Schnyder, J.
    Monahan, J.
    Smith, W.
    Hope, H.
    Kelly, D.
    Burt, D.
    Huff, E.
    Kaul, A.
    Hildebrand, A.
    Burnette, B.
    Klug, N.
    Bangs, M.
    Gordon, D.
    ANNALS OF THE RHEUMATIC DISEASES, 2020, 79 : 1006 - 1006
  • [16] Final results from the ZENITH-1 study: Oral administration of plasma kallikrein inhibitor BCX7353 for the treatment of attacks in patients with hereditary angioedema
    Longhurst, H. J.
    Stobiecki, M.
    Zanichelli, A.
    Huissoon, A.
    Moldovan, D.
    Maurer, M.
    Magerl, M.
    Cancian, M.
    Senter, R.
    Manson, A.
    Aygoeren-Puersuen, E.
    Grivcheva-Panovska, V
    Hagin, D.
    Steiner, U.
    Kiani-Alikhan, S.
    Agmon-Levin, N.
    Bygum, A.
    Aberer, W.
    Faust, S. N.
    Launay, D.
    Gompels, M.
    Triggiani, M.
    Bethune, C.
    Reshef, A.
    Cornpropst, M.
    Dobo, S.
    Van Dyke, S.
    Murray, S.
    Collis, P.
    Sheridan, W. P.
    Farkas, H.
    Cicardi, M.
    ALLERGY, 2019, 74 : 10 - 11
  • [17] RESULTS OF A PHASE I SAFETY TOLERABILITY AND PHARMACOKINETIC STUDY OF ANA598, A NON-NUCLEOSIDE NS5B POLYMERASE INHIBITOR, IN HEALTHY VOLUNTEERS
    Rahimy, Mohamad H.
    Crowley, Constance A.
    Freddo, James L.
    Sergeeva, Maria V.
    Golec, Brent
    HEPATOLOGY, 2008, 48 (04) : 1026A - 1026A
  • [18] Oral ferroportin inhibitor VIT-2763: First-in-human, phase 1 study in healthy volunteers
    Richard, Frank
    van Lier, Jan Jaap
    Roubert, Bernard
    Haboubi, Teba
    Gohring, Udo-Michael
    Durrenberger, Franz
    AMERICAN JOURNAL OF HEMATOLOGY, 2020, 95 (01) : 68 - 77
  • [19] Phase 1 Study of the Safety, Pharmacokinetics and Pharmacodynamics of Teneligliptin, a New DPP-IV Inhibitor, in Healthy Volunteers
    Kumagai, Yuji
    Fujita, Tomoe
    Kawaguchi, Atsuhiro
    Hayashi, Yoshiharu
    Kondou, Kazuoki
    DIABETES, 2010, 59 : A193 - A193
  • [20] Pharmacokinetic, pharmacodynamic, and safety profiles of PEGylated interferon beta-1a in healthy volunteers: Results from two Phase 1 clinical studies
    Davar, Gudarz
    Richman, Sandra
    Hitchman, Stacy
    Glick, Gabrielle
    Subramanyam, Meena
    Hu, Xiao
    Lerner, Michaela
    Miller, Larisa
    Nestorov, Ivan
    Liu, Shifang
    Zhu, Ying
    Baker, Darren
    Panzara, Michael A.
    CYTOKINE, 2009, 48 (1-2) : 21 - 21
12345