Oxytocin and socioemotional aging: Current knowledge and future trends

被引:61
作者
Ebner, Natalie C. [1 ]
Maura, Gabriela M. [1 ]
MacDonald, Kai [2 ]
Westberg, Lars [3 ]
Fischer, Hakan [4 ,5 ]
机构
[1] Univ Florida, Dept Psychol, Gainesville, FL 32611 USA
[2] Univ Calif San Diego, Dept Psychiat, La Jolla, CA 92093 USA
[3] Univ Gothenburg, Dept Pharmacol, Gothenburg, Sweden
[4] Stockholm Univ, Dept Psychol, S-10691 Stockholm, Sweden
[5] Karolinska Inst, Aging Res Ctr, Stockholm, Sweden
来源
FRONTIERS IN HUMAN NEUROSCIENCE | 2013年 / 7卷
基金
瑞典研究理事会;
关键词
oxytocin; aging; socioemotional functioning; amygdala; anterior cingulate; AGE-RELATED DIFFERENCES; RECEPTOR OXTR GENE; ADULT LIFE-SPAN; OLDER EMOTIONAL FACES; INTRANASAL OXYTOCIN; SOCIAL-BEHAVIOR; HUMAN BRAIN; CENTRAL AMYGDALA; NEGATIVE AFFECT; HUMAN-MEMORY;
D O I
10.3389/fnhum.2013.00487
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The oxytocin (OT) system is involved in various aspects of social cognition and prosocial behavior. Specifically, OT has been examined in the context of social memory, emotion recognition, cooperation, trust, empathy, and bonding, and-though evidence is somewhat mixed-intranasal OT appears to benefit aspects of socioemotional functioning. However, most of the extant data on aging and OT is from animal research and human OT research has focused largely on young adults. As such, though we know that various socioemotional capacities change with age, we know little about whether age-related changes in the OT system may underlie age-related differences in socioemotional functioning. In this review, we take a genetic-neuro-behavioral approach and evaluate current evidence on age-related changes in the OT system as well as the putative effects of these alterations on age-related socioemotional functioning. Looking forward, we identify informational gaps and propose an Age-Related Genetic, Neurobiological, Sociobehavioral Model of Oxytocin (AGeNeS-OT model) which may structure and inform investigations into aging-related genetic, neural, and sociocognitive processes related to OT. As an exemplar of the use of the model, we report exploratory data suggesting differences in socioemotional processing associated with genetic variation in the oxytocin receptor gene (OXTR) in samples of young and older adults. Information gained from this arena has translational potential in depression, social stress, and anxiety-all of which have high relevance in aging-and may contribute to reducing social isolation and improving well-being of individuals across the lifespan.
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页数:14
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