Targeting sphingosine kinase 1 (SphK1) and apoptosis by colon-specific delivery formula of resveratrol in treatment of experimental ulcerative colitis in rats

被引:60
|
作者
Abdin, Amany A. [1 ]
机构
[1] Tanta Univ, Fac Med, Dept Pharmacol, Tanta 31527, Egypt
关键词
Ulcerative colitis; Sphingosine kinase; Sesveratrol; Colon-specific delivery formula; INFLAMMATORY-BOWEL-DISEASE; TRANS-RESVERATROL; COLORECTAL-CANCER; OXAZOLONE COLITIS; EXPRESSION; MECHANISMS; INHIBITORS; SPHINGOSINE-1-PHOSPHATE; 1-PHOSPHATE; EFFICACY;
D O I
10.1016/j.ejphar.2013.08.040
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Ulcerative colitis (DC) is a chronic inflammatory bowel disorder (IBD) that has an elevated risk of developing into colon cancer. In trials to develop new therapeutic alternatives for UC, it is important to fulfill modifying effects on pathogenic targets and to reach the colon in a high concentration. Thus, the current work has investigated a colon-specific delivery formula of resveratrol in targeting sphingosine kinase 1 (SphK1) and apoptotic pathways to control pathogenesis and its progression to any expected neoplasm. This work was conducted on 40 Wister albino rats equally divided into 4 groups where group I served as the normal control group. The untreated oxazolone-induced colitis in group II exhibited significant increase in SphK1 activity as well as activity of both myeloperoxiclase (MPO) and caspase-3 with concomitant mild DNA fragmentation in colonic tissue. Colonic SphK1 activity showed significant positive correlation with the disease activity index (DAI) and histopathological score in this group. Comparable with treatment by the native resveratrol formula, nRes (group Ill), treatment by the colonspecific delivery resveratrol formula, cRes (group IV) caused significant decrease in the activity of SphK1 and MPO with massive DNA fragmentation in colonic tissue and non significant change in caspase-3 activity. The lowest DAl and histopathological score have been recorded in the group treated by the colon-specific delivery resveratrol formula. In conclusion, the anti-inflammatory and apoptotic effects of resveratrol could be attributed to its inhibitory effect on sphingosine kinase 1 (SphK1) providing a useful therapeutic tool to break the link between inflammation and carcinogenesis risk in ulcerative colitis. (C) 2013 Elsevier B.V. All rights reserved.
引用
收藏
页码:145 / 153
页数:9
相关论文
共 10 条
  • [1] MiR-506 suppresses liver cancer angiogenesis through targeting sphingosine kinase 1 (SPHK1) mRNA
    Lu, Zhanping
    Zhang, Weiying
    Gao, Shan
    Jiang, Qiulei
    Xiao, Zelin
    Ye, Lihong
    Zhang, Xiaodong
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 468 (1-2) : 8 - 13
  • [2] Colon-specific delivery of isoliquiritigenin by oral edible zein/caseate nanocomplex for ulcerative colitis treatment
    Xiao, Meng
    Wu, Shuyang
    Cheng, Yanfen
    Ma, Jiaqi
    Luo, Xi
    Chang, Liang
    Zhang, Chen
    Chen, Jianping
    Zou, Liang
    You, Yu
    Zhang, Jinming
    FRONTIERS IN CHEMISTRY, 2022, 10
  • [3] Microrna-1 Is Decreased By Hypoxia And Contributes To The Development Of Experimental Pulmonary Hypertension Via Regulation Of Sphingosine Kinase 1 (sphk1)
    Sysol, J. R.
    Chen, J.
    Singla, S.
    Natarajan, V.
    Machado, R. F.
    AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2016, 193
  • [4] Hesperidin modulates dextran sulfate sodium-induced ulcerative colitis in rats: Targeting sphingosine kinase-1-sphingosine 1 phosphate signaling pathway, mitochondrial biogenesis, inflammation, and apoptosis
    Shafik, Noha M.
    Gaber, Rasha A.
    Mohamed, Darin A.
    Ebeid, Abla M.
    JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2019, 33 (06)
  • [5] Metformin alleviates inflammation in oxazolone induced ulcerative colitis in rats: plausible role of sphingosine kinase 1/sphingosine 1 phosphate signaling pathway
    El-Mahdy, Nageh Ahmed
    El-Sayad, Magda El-Sayed
    El-Kadem, Aya Hassan
    Abu-Risha, Sally EL-Sayed
    IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY, 2021, 43 (02) : 192 - 202
  • [6] Beneficial anti-inflammatory effect of paeonol self-microemulsion-loaded colon-specific capsules on experimental ulcerative colitis rats
    Zong, Shiyu
    Pu, Yiqiong
    Li, Suyun
    Xu, Benliang
    Zhang, Yong
    Zhang, Tong
    Wang, Bing
    ARTIFICIAL CELLS NANOMEDICINE AND BIOTECHNOLOGY, 2018, 46 : S324 - S335
  • [7] LncRNA HULC promotes non-small cell lung cancer cell proliferation and inhibits the apoptosis by up-regulating sphingosine kinase 1 (SPHK1) and its downstream PI3K/Akt pathway
    Liu, L.
    Zhou, X-Y
    Zhang, J-Q
    Wang, G-G
    He, J.
    Chen, Y-Y
    Huang, C.
    Li, L.
    Li, S-Q
    EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, 2018, 22 (24) : 8722 - 8730
  • [8] Discovery of a Colon-Targeted Azo Prodrug of Tofacitinib through the Establishment of Colon-Specific Delivery Systems Constructed by 5-ASA-PABA-MAC and 5-ASA-PABA-Diamine for the Treatment of Ulcerative Colitis
    Zhao, Jiaxing
    Zhang, Bing
    Mao, Qing
    Ping, Kunqi
    Zhang, Peng
    Lin, Fengwei
    Liu, Dan
    Feng, Yao
    Sun, Ming
    Zhang, Yan
    Li, Qiu Hua
    Zhang, Tingjian
    Mou, Yanhua
    Wang, Shaojie
    JOURNAL OF MEDICINAL CHEMISTRY, 2022, 65 (06) : 4926 - 4948
  • [9] Colon-specific delivery of R68070, a new thromboxane synthase inhibitor, using chitosan capsules: Therapeutic effects against 2,4,6-trinitrobenzene sulfonic acid-induced ulcerative colitis in rats
    Tozaki, H
    Fujita, T
    Odoriba, T
    Terabe, A
    Suzuki, T
    Tanaka, C
    Okabe, S
    Muranishi, S
    Yamamoto, A
    LIFE SCIENCES, 1999, 64 (13) : 1155 - 1162
  • [10] Ambroxol, a mucolytic agent, boosts HO-1, suppresses NF-κB, and decreases the susceptibility of the inflamed rat colon to apoptosis: A new treatment option for treating ulcerative colitis
    Cavalu, Simona
    Sharaf, Hossam
    Saber, Sameh
    Youssef, Mahmoud E.
    Abdelhamid, Amir Mohamed
    Mourad, Ahmed A. E.
    Ibrahim, Samar
    Allam, Shady
    Elgharabawy, Rehab Mohamed
    El-Ahwany, Eman
    Amin, Noha A.
    Shata, Ahmed
    Eldegla, Mai
    Atef, Marina
    Aboraya, Maii
    Mohamed, Mayar
    Anz, Niera
    Abd Elmotelb, Dina
    Gabr, Fayrouz
    Elzablawy, Dalia
    Hamada, Menna
    Yehia, Amr
    Osama, Dalia
    Mohammed, Osama A.
    FASEB JOURNAL, 2022, 36 (09):