Targeting sphingosine kinase 1 (SphK1) and apoptosis by colon-specific delivery formula of resveratrol in treatment of experimental ulcerative colitis in rats
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作者:
Abdin, Amany A.
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Tanta Univ, Fac Med, Dept Pharmacol, Tanta 31527, EgyptTanta Univ, Fac Med, Dept Pharmacol, Tanta 31527, Egypt
Abdin, Amany A.
[1
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机构:
[1] Tanta Univ, Fac Med, Dept Pharmacol, Tanta 31527, Egypt
Ulcerative colitis (DC) is a chronic inflammatory bowel disorder (IBD) that has an elevated risk of developing into colon cancer. In trials to develop new therapeutic alternatives for UC, it is important to fulfill modifying effects on pathogenic targets and to reach the colon in a high concentration. Thus, the current work has investigated a colon-specific delivery formula of resveratrol in targeting sphingosine kinase 1 (SphK1) and apoptotic pathways to control pathogenesis and its progression to any expected neoplasm. This work was conducted on 40 Wister albino rats equally divided into 4 groups where group I served as the normal control group. The untreated oxazolone-induced colitis in group II exhibited significant increase in SphK1 activity as well as activity of both myeloperoxiclase (MPO) and caspase-3 with concomitant mild DNA fragmentation in colonic tissue. Colonic SphK1 activity showed significant positive correlation with the disease activity index (DAI) and histopathological score in this group. Comparable with treatment by the native resveratrol formula, nRes (group Ill), treatment by the colonspecific delivery resveratrol formula, cRes (group IV) caused significant decrease in the activity of SphK1 and MPO with massive DNA fragmentation in colonic tissue and non significant change in caspase-3 activity. The lowest DAl and histopathological score have been recorded in the group treated by the colon-specific delivery resveratrol formula. In conclusion, the anti-inflammatory and apoptotic effects of resveratrol could be attributed to its inhibitory effect on sphingosine kinase 1 (SphK1) providing a useful therapeutic tool to break the link between inflammation and carcinogenesis risk in ulcerative colitis. (C) 2013 Elsevier B.V. All rights reserved.
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Nankai Univ, State Key Lab Med Chem Biol, Dept Canc Res, Coll Life Sci, Tianjin 300071, Peoples R ChinaNankai Univ, State Key Lab Med Chem Biol, Dept Canc Res, Coll Life Sci, Tianjin 300071, Peoples R China
Lu, Zhanping
Zhang, Weiying
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Nankai Univ, State Key Lab Med Chem Biol, Dept Canc Res, Coll Life Sci, Tianjin 300071, Peoples R ChinaNankai Univ, State Key Lab Med Chem Biol, Dept Canc Res, Coll Life Sci, Tianjin 300071, Peoples R China
Zhang, Weiying
Gao, Shan
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Nankai Univ, State Key Lab Med Chem Biol, Dept Canc Res, Coll Life Sci, Tianjin 300071, Peoples R ChinaNankai Univ, State Key Lab Med Chem Biol, Dept Canc Res, Coll Life Sci, Tianjin 300071, Peoples R China
Gao, Shan
Jiang, Qiulei
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Nankai Univ, State Key Lab Med Chem Biol, Dept Canc Res, Coll Life Sci, Tianjin 300071, Peoples R ChinaNankai Univ, State Key Lab Med Chem Biol, Dept Canc Res, Coll Life Sci, Tianjin 300071, Peoples R China
Jiang, Qiulei
Xiao, Zelin
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Nankai Univ, State Key Lab Med Chem Biol, Dept Canc Res, Coll Life Sci, Tianjin 300071, Peoples R ChinaNankai Univ, State Key Lab Med Chem Biol, Dept Canc Res, Coll Life Sci, Tianjin 300071, Peoples R China
Xiao, Zelin
Ye, Lihong
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Nankai Univ, Dept Biochem, Coll Life Sci, State Key Lab Med Chem Biol, Tianjin 300071, Peoples R ChinaNankai Univ, State Key Lab Med Chem Biol, Dept Canc Res, Coll Life Sci, Tianjin 300071, Peoples R China
Ye, Lihong
Zhang, Xiaodong
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Nankai Univ, State Key Lab Med Chem Biol, Dept Canc Res, Coll Life Sci, Tianjin 300071, Peoples R ChinaNankai Univ, State Key Lab Med Chem Biol, Dept Canc Res, Coll Life Sci, Tianjin 300071, Peoples R China
机构:
Chengdu Univ Tradit Chinese Med, Pharm Sch, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R ChinaChengdu Univ Tradit Chinese Med, Pharm Sch, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China
Xiao, Meng
Wu, Shuyang
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Chengdu Univ Tradit Chinese Med, Pharm Sch, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R ChinaChengdu Univ Tradit Chinese Med, Pharm Sch, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China
Wu, Shuyang
Cheng, Yanfen
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Chengdu Univ Tradit Chinese Med, Pharm Sch, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R ChinaChengdu Univ Tradit Chinese Med, Pharm Sch, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China
Cheng, Yanfen
Ma, Jiaqi
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Chengdu Univ Tradit Chinese Med, Pharm Sch, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R ChinaChengdu Univ Tradit Chinese Med, Pharm Sch, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China
Ma, Jiaqi
Luo, Xi
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Chengdu Univ Tradit Chinese Med, Pharm Sch, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R ChinaChengdu Univ Tradit Chinese Med, Pharm Sch, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China
Luo, Xi
Chang, Liang
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Chengdu Univ Tradit Chinese Med, Pharm Sch, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R ChinaChengdu Univ Tradit Chinese Med, Pharm Sch, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China
Chang, Liang
Zhang, Chen
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Chengdu Univ Tradit Chinese Med, Pharm Sch, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R ChinaChengdu Univ Tradit Chinese Med, Pharm Sch, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China
Zhang, Chen
Chen, Jianping
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Univ Hong Kong, Li Ka Shing Fac Med, Sch Chinese Med, Hong Kong, Peoples R ChinaChengdu Univ Tradit Chinese Med, Pharm Sch, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China
Chen, Jianping
Zou, Liang
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Chengdu Univ, Sch Food & Biol Engn, Key Lab Coarse Cereal Proc, Minist Agr & Rural Affairs, Chengdu, Peoples R ChinaChengdu Univ Tradit Chinese Med, Pharm Sch, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China
Zou, Liang
You, Yu
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Chengdu Univ Tradit Chinese Med, Pharm Sch, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R ChinaChengdu Univ Tradit Chinese Med, Pharm Sch, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China
You, Yu
Zhang, Jinming
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Chengdu Univ Tradit Chinese Med, Pharm Sch, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R ChinaChengdu Univ Tradit Chinese Med, Pharm Sch, State Key Lab Southwestern Chinese Med Resources, Chengdu, Peoples R China
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Shanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, Shanghai, Peoples R China
Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R ChinaShanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, Shanghai, Peoples R China
Zong, Shiyu
Pu, Yiqiong
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Shanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, Shanghai, Peoples R ChinaShanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, Shanghai, Peoples R China
Pu, Yiqiong
Li, Suyun
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Shanghai Univ Tradit Chinese Med, Sch Basic Med Sci, Shanghai, Peoples R ChinaShanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, Shanghai, Peoples R China
Li, Suyun
Xu, Benliang
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Shanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, Shanghai, Peoples R ChinaShanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, Shanghai, Peoples R China
Xu, Benliang
Zhang, Yong
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Shanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, Shanghai, Peoples R China
Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R ChinaShanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, Shanghai, Peoples R China
Zhang, Yong
Zhang, Tong
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Shanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, Shanghai, Peoples R China
Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R ChinaShanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, Shanghai, Peoples R China
Zhang, Tong
Wang, Bing
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Shanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, Shanghai, Peoples R China
Shanghai Univ Tradit Chinese Med, Sch Pharm, Shanghai, Peoples R ChinaShanghai Univ Tradit Chinese Med, Expt Ctr Teaching & Learning, Shanghai, Peoples R China
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PUMCH, Dept Thorac Surg Peking, 1 Shuaifuyuan, Beijing, Peoples R China
Chinese Acad Med Sci, Peking Union Med Coll, 1 Shuaifuyuan, Beijing, Peoples R ChinaPUMCH, Dept Thorac Surg Peking, 1 Shuaifuyuan, Beijing, Peoples R China
Liu, L.
Zhou, X-Y
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PUMCH, Dept Thorac Surg Peking, 1 Shuaifuyuan, Beijing, Peoples R China
Chinese Acad Med Sci, Peking Union Med Coll, 1 Shuaifuyuan, Beijing, Peoples R ChinaPUMCH, Dept Thorac Surg Peking, 1 Shuaifuyuan, Beijing, Peoples R China
Zhou, X-Y
Zhang, J-Q
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PUMCH, Dept Thorac Surg Peking, 1 Shuaifuyuan, Beijing, Peoples R China
Chinese Acad Med Sci, Peking Union Med Coll, 1 Shuaifuyuan, Beijing, Peoples R ChinaPUMCH, Dept Thorac Surg Peking, 1 Shuaifuyuan, Beijing, Peoples R China
Zhang, J-Q
Wang, G-G
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PUMCH, Dept Thorac Surg Peking, 1 Shuaifuyuan, Beijing, Peoples R China
Chinese Acad Med Sci, Peking Union Med Coll, 1 Shuaifuyuan, Beijing, Peoples R ChinaPUMCH, Dept Thorac Surg Peking, 1 Shuaifuyuan, Beijing, Peoples R China
Wang, G-G
He, J.
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PUMCH, Dept Thorac Surg Peking, 1 Shuaifuyuan, Beijing, Peoples R China
Chinese Acad Med Sci, Peking Union Med Coll, 1 Shuaifuyuan, Beijing, Peoples R ChinaPUMCH, Dept Thorac Surg Peking, 1 Shuaifuyuan, Beijing, Peoples R China
He, J.
Chen, Y-Y
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PUMCH, Dept Thorac Surg Peking, 1 Shuaifuyuan, Beijing, Peoples R China
Chinese Acad Med Sci, Peking Union Med Coll, 1 Shuaifuyuan, Beijing, Peoples R ChinaPUMCH, Dept Thorac Surg Peking, 1 Shuaifuyuan, Beijing, Peoples R China
Chen, Y-Y
Huang, C.
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PUMCH, Dept Thorac Surg Peking, 1 Shuaifuyuan, Beijing, Peoples R China
Chinese Acad Med Sci, Peking Union Med Coll, 1 Shuaifuyuan, Beijing, Peoples R ChinaPUMCH, Dept Thorac Surg Peking, 1 Shuaifuyuan, Beijing, Peoples R China
Huang, C.
Li, L.
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PUMCH, Dept Thorac Surg Peking, 1 Shuaifuyuan, Beijing, Peoples R China
Chinese Acad Med Sci, Peking Union Med Coll, 1 Shuaifuyuan, Beijing, Peoples R ChinaPUMCH, Dept Thorac Surg Peking, 1 Shuaifuyuan, Beijing, Peoples R China
Li, L.
Li, S-Q
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PUMCH, Dept Thorac Surg Peking, 1 Shuaifuyuan, Beijing, Peoples R China
Chinese Acad Med Sci, Peking Union Med Coll, 1 Shuaifuyuan, Beijing, Peoples R ChinaPUMCH, Dept Thorac Surg Peking, 1 Shuaifuyuan, Beijing, Peoples R China
机构:
Univ Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, RomaniaUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania
Cavalu, Simona
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Sharaf, Hossam
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Saber, Sameh
Youssef, Mahmoud E.
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Delta Univ Sci & Technol, Fac Pharm, Dept Pharmacol, Gamasa, EgyptUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania
Youssef, Mahmoud E.
Abdelhamid, Amir Mohamed
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Delta Univ Sci & Technol, Fac Pharm, Dept Pharmacol, Gamasa, EgyptUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania
Abdelhamid, Amir Mohamed
Mourad, Ahmed A. E.
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Port Said Univ, Fac Pharm, Dept Pharmacol & Toxicol, Port Said, EgyptUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania
Mourad, Ahmed A. E.
Ibrahim, Samar
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Ahram Canadian Univ, Fac Pharm, Dept Pharm Practice, Giza, EgyptUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania
Ibrahim, Samar
Allam, Shady
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Menoufia Univ, Fac Pharm, Dept Pharmacol & Toxicol, Menoufia, EgyptUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania
Allam, Shady
Elgharabawy, Rehab Mohamed
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Tanta Univ, Fac Pharm, Pharmacol & Toxicol Dept, Tanta, EgyptUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania
Elgharabawy, Rehab Mohamed
El-Ahwany, Eman
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Theodor Bilharz Res Inst, Dept Immunol, Giza, EgyptUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania
El-Ahwany, Eman
Amin, Noha A.
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Theodor Bilharz Res Inst, Dept Haematol, Giza, EgyptUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania
Amin, Noha A.
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Shata, Ahmed
Eldegla, Mai
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Delta Univ Sci & Technol, Fac Pharm, Dept Biochem, Gamasa, EgyptUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania
Eldegla, Mai
Atef, Marina
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Delta Univ Sci & Technol, Fac Pharm, Dept Biochem, Gamasa, EgyptUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania
Atef, Marina
Aboraya, Maii
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Delta Univ Sci & Technol, Fac Pharm, Dept Biochem, Gamasa, EgyptUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania
Aboraya, Maii
Mohamed, Mayar
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Delta Univ Sci & Technol, Fac Pharm, Dept Biochem, Gamasa, EgyptUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania
Mohamed, Mayar
Anz, Niera
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Delta Univ Sci & Technol, Fac Pharm, Dept Biochem, Gamasa, EgyptUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania
Anz, Niera
Abd Elmotelb, Dina
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Delta Univ Sci & Technol, Fac Pharm, Dept Biochem, Gamasa, EgyptUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania
Abd Elmotelb, Dina
Gabr, Fayrouz
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Delta Univ Sci & Technol, Fac Pharm, Dept Biochem, Gamasa, EgyptUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania
Gabr, Fayrouz
Elzablawy, Dalia
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Delta Univ Sci & Technol, Fac Pharm, Dept Biochem, Gamasa, EgyptUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania
Elzablawy, Dalia
Hamada, Menna
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Delta Univ Sci & Technol, Fac Pharm, Dept Biochem, Gamasa, EgyptUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania
Hamada, Menna
Yehia, Amr
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Delta Univ Sci & Technol, Fac Pharm, Dept Biochem, Gamasa, EgyptUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania
Yehia, Amr
Osama, Dalia
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Delta Univ Sci & Technol, Fac Pharm, Dept Biochem, Gamasa, EgyptUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania
Osama, Dalia
Mohammed, Osama A.
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Ain Shams Univ, Fac Med, Dept Clin Pharmacol, Cairo, Egypt
Bisha Univ, Fac Med, Dept Clin Pharmacol, Bisha, Saudi ArabiaUniv Oradea, Fac Med & Pharm, P Ta 1 Decembrie 10, Oradea 410087, Romania