Significance of endangered and threatened plant natural products in the control of human disease

被引：72

作者：

Ibrahim, Mohamed Ali ^{[1
,4
,8
]}

Na, MinKyun ^{[9
]}

Oh, Joonseok ^{[1
]}

Schinazi, Raymond F. ^{[10
,11
]}

McBrayer, Tami R. ^{[12
]}

Whitaker, Tony ^{[12
]}

Doerksen, Robert J. ^{[2
,4
]}

Newman, David J. ^{[13
]}

Zachos, Louis G. ^{[3
]}

Hamann, Mark T. ^{[1
,5
,6
,7
]}

机构：

[1] Univ Mississippi, Sch Pharm, Dept Pharmacognosy, University, MS 38677 USA

[2] Univ Mississippi, Sch Pharm, Dept Med Chem, University, MS 38677 USA

[3] Univ Mississippi, Sch Pharm, Dept Geol & Geol Engn, University, MS 38677 USA

[4] Univ Mississippi, Sch Pharm, Natl Ctr Nat Prod Res, University, MS 38677 USA

[5] Univ Mississippi, Sch Pharm, Dept Pharmacol, University, MS 38677 USA

[6] Univ Mississippi, Sch Pharm, Dept Chem, University, MS 38677 USA

[7] Univ Mississippi, Sch Pharm, Dept Biochem, University, MS 38677 USA

[8] Natl Res Ctr, Dept Chem Nat Cpds, Cairo 12622, Egypt

[9] Chungnam Natl Univ, Coll Pharm, Taejon 305764, South Korea

[10] Emory Univ, Dept Pediat, Ctr AIDS Res, Atlanta, GA 30322 USA

[11] Vet Affairs Med Ctr, Decatur, GA 30033 USA

[12] RFS Pharma LLC, Tucker, GA 30084 USA

[13] US Natl Canc Inst, Nat Prod Branch, NIH, Bethesda, MD 21702 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2013年 / 110卷 / 42期

基金：

新加坡国家研究基金会; 美国国家卫生研究院;

关键词：

endangered plants; hepatitis C virus; diabetes mellitus; TYROSINE-PHOSPHATASE; 1B; HEPATITIS-C VIRUS; INHIBITION; EXTINCTION; DIVERSITY; OBESITY; DRUGS; MICE;

D O I：

10.1073/pnas.1311528110

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

One in five of the world's plant species is threatened with extinction according to the 2010 first global analysis of extinction risk. Tilman et al. predicted a massive ecological change to terrestrial plants within the next 50-100 y, accompanied by an increase in the number of global plant species facing extinction [Tilman D, et al. (2001) Proc Natl Acad Sci USA 98(10): 5433-5440]. Most of the drug-producing plant families contain endangered species never previously studied for their utility to human health, which strongly validates the need to prioritize protection and assessment of these fragile and endangered groups [Zhu F, et al. (2011) Proc Natl Acad Sci USA 108(31): 12943-12948]. With little prior attention given to endangered and rare plant species, this report provides strong justification for conservation of the rare plant Diplostephium rhododendroides Hieron., as well as other potential drug-producing endangered species in this and other groups.

引用

页码：16832 / 16837

页数：6

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