Usefulness of the whole-blood interferon-gamma release assay for diagnosis of extrapulmonary tuberculosis

被引：57
作者：
Song, Kyoung-Ho [2 ]
Jeon, Jae Hyun [2 ]
Park, Wan Beom [2 ]
Kim, Sung-Han [2 ]
Park, Kyoung Un [3 ]
Kim, Nam Joong [2 ]
Oh, Myoung-don [2 ]
Kim, Hong Bin [1 ,2 ]
Choe, Kang Won [2 ]
机构：
[1] Seoul Natl Univ, Bundang Hosp, Dept Internal Med, Songnam 463707, South Korea
[2] Seoul Natl Univ, Coll Med, Dept Internal Med, Seoul 151, South Korea
[3] Seoul Natl Univ, Coll Med, Dept Lab Med, Seoul 151, South Korea
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2009年 / 63卷 / 02期
关键词：
Tuberculosis; Interferon-gamma; Diagnosis; Lymphadenitis; Spondylitis; CELL-BASED ASSAY; MYCOBACTERIUM-TUBERCULOSIS; SKIN-TEST; PULMONARY TUBERCULOSIS; ACTIVE PULMONARY; INFECTION; TESTS; LYMPHADENITIS; SENSITIVITY; ANTIGENS;
D O I：
10.1016/j.diagmicrobio.2008.10.013
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
The whole-blood interferon-gamma enzyme-linked immunosorbent assay (QuantiFERON-TB Gold [QFT-G]; Cellestis, Carnegie, Australia) has been studied mainly for diagnosing active pulmonary tuberculosis (TB) or latent TB. We prospectively evaluated its diagnostic usefulness in patients Suspected with extrapulmonary TB (EP-TB). Of the 100 adult patients with suspected EP-TB, 43 were classified as "confirmed" EP-TB and 5 as "probable" EP-TB. Of the 48 with EP-TB, 27 (56%) were diagnosed with TB lymphadenitis and 11 (17%) with skeletal TB. The overall sensitivity and specificity of the assay were 69% (95% confidence interval [CI95], 53-81%) and 82% (CI95, 69-91%), respectively. Among 44 patients presented with cervical lymphadenopathy, the QFT-G assay showed 86% (CI95, 64-97%) sensitivity and 87% (CI95, 66-97%) specificity, whereas in 28 with skeletal involvement, the sensitivity and specificity of the assay were 45% (CI95, 17-77%) and 81% (CI95, 54-96%), respectively. These suboptimal diagnostic performances suggest that the QFT-G assay alone is not sufficient for the diagnosis of EP-TB. (c) 2009 Elsevier Inc. All rights reserved.
引用
收藏
页码：182 / 187
页数：6
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