Left ventricle diastolic dysfunction in a sample of prediabetic adults from Baghdad, Iraq

Background Prediabetes is a metabolic state in which people are not diabetics but also cannot be considered normal in terms of cutoff points of glycated hemoglobin or fasting plasma glucose. Those people are at higher risk of progression to type 2 diabetes mellitus and to develop many of the diabetes micro- and macro-vascular complications even before a diagnosis of diabetes has been established. One of the earliest cardiac manifestations of diabetic heart failure is left ventricle diastolic dysfunction. Objectives To identify diastolic dysfunction as early complication of prediabetes among adults in Baghdad, Iraq, and to determine associated risk factors among those individuals. Subjects and methods This cross-sectional study enrolled 38 adults (20-79 years) with prediabetes in the setting of primary healthcare centers in Baghdad, Iraq, compared with 38 adults (age and sex matched) without prediabetes. People with any condition that interfere with glycated hemoglobin level were excluded. Data were collected through direct interview. Anthropometric measurements and laboratory analysis were done to measure fasting plasma glucose, glycated hemoglobin, and lipid profile. Echocardiography was done to assess left ventricle diastolic function. Results Prediabetes was significantly associated with left ventricle diastolic dysfunction (95% CI 0.23, 0.53) than those without prediabetes (95% CI 0.03, 0.21) (p = 0.013). Conclusions Left ventricle diastolic dysfunction is an early manifestation of cardiac abnormalities associated with prediabetes. Those people share same factors with those having type 2 diabetes mellitus. More attention should be paid to identify those individuals correctly in order to intervene instantly.