Synthesis and capillary electrophoretic analysis of enantiomerically enriched reference standards of MDMA and its main metabolites

被引：27
作者：
Pizarro, N
de la Torre, R
Farré, M
Segura, J
Llebaria, A
Joglar, J
机构：
[1] CSIC, IIQAB, Dept Biol Organ Chem, E-08034 Barcelona, Spain
[2] Inst Municipal Invest Med, Pharmacol Res Unit, E-08003 Barcelona, Spain
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2002年 / 10卷 / 04期
关键词：
D O I：
10.1016/S0968-0896(01)00367-4
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Enantiomerically-enriched (S)-3,4-methylenedioxymethamphetamine (MDMA) and its main metabolites (S)-4-hydroxy-3-methoxymethamphetamine (HMMA) and (S)-3,4-dihydroxymethamphetamine (HHMA) were prepared for unequivocal identification of the differential enantioselective metabolism of these compounds as well as for its application in the analysis of biological samples. Capillary electrophoresis with cyclodextrin derivatives and a chemical correlation of (S)-MDMA. (S)-HMMA and (S)-HHMA has been performed to assign the absolute stereochemistry of major isomers in analytical standards enriched with such enantiomers. (C) 2002 Elsevier Science Ltd. All rights reserved.
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页码：1085 / 1092
页数：8
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