Epigenetic Control of Gene Function in Enamel Development

被引：10

作者：

Fan, Yi ^{[1
,2
]}

Zhou, Yachuan ^{[1
]}

Zhou, Xuedong ^{[1
]}

Xu, Xin ^{[3
]}

Pi, Caixia ^{[1
]}

Xu, Ruoshi ^{[1
]}

Zheng, Liwei ^{[1
,3
]}

机构：

[1] Sichuan Univ, West China Sch Stomatol, State Key Lab Oral Dis, Chengdu, Sichuan, Peoples R China

[2] Harvard Univ, Sch Dent Med, Dept Oral Med Infect & Immun, Cambridge, MA 02138 USA

[3] Johns Hopkins Univ, Sch Med, Baltimore, MD 21218 USA

来源：

CURRENT STEM CELL RESEARCH & THERAPY | 2015年 / 10卷 / 05期

关键词：

Amelogenesis; epigenetics; regeneration; stem cells; tooth development; IN-VIVO TRANSFECTION; STEM-CELLS; TOOTH MORPHOGENESIS; MICRORNA EXPRESSION; DIFFERENTIATION; AMELOGENIN; GROWTH; PROLIFERATION; EPITHELIUM; MUTATIONS;

D O I：

10.2174/1574888X10666150305104730

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

Amelogenesis consists of various development phases that are tightly controlled by the exquisitely sequential and reciprocal interactions between tooth epithelium and mesenchyme. Subtle alterations during this complex physiological and biochemical development events could lead to severe enamel defects in shape, color and structure. Modulations in microRNA, DNA methylation and chromatin modifications are emerging as important regulatory mechanisms during tooth development. The growing field of epigenetic regulations in enamel development provides excellent opportunities to identify novel enamel-related disease makers and to explore the potential therapeutic methods. The present review will give an overview in the current research progress in epigenetic regulation events during tooth development with a highlight in the aspects of enamel formation.

引用

页码：405 / 411

页数：7

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