Anti-HIV activity of quassinoids

被引：45
作者：
Okano, M
Fukamiya, N
Tagahara, K
Cosentino, M
Lee, TTY
MorrisNatschke, S
Lee, KH
机构：
[1] HIROSHIMA UNIV,FAC INTEGRATED ARTS & SCI,DEPT INTERDISCIPLINARY STUDIES NAT ENVIRONM,HIGASHIHIROSHIMA 739,JAPAN
[2] KOBE PHARMACEUT UNIV,FAC PHARMACEUT SCI,KOBE,HYOGO 658,JAPAN
[3] BIOTECH RES LABS INC,ROCKVILLE,MD 20850
[4] UNIV N CAROLINA,SCH MED,CHAPEL HILL,NC 27599
[5] UNIV N CAROLINA,SCH PHARM,DIV MED CHEM & NAT PROD,NAT PROD LAB,CHAPEL HILL,NC 27599
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 06期
关键词：
D O I：
10.1016/0960-894X(96)00096-0
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Eighteen quassinoid glycosides and nine known quassinoids were tested for inhibitory activity against HIV replication in H9 lymphocytic cells. Of the compounds tested, shinjulactone C (20) demonstrated the highest anti-HIV activity (EC(50) = 10.6 mu M) in the absence of cytotoxicity with a therapeutic index of >25.
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收藏
页码：701 / 706
页数：6
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