Anti-HIV activity of quassinoids

被引：45

作者：

Okano, M

Fukamiya, N

Tagahara, K

Cosentino, M

Lee, TTY

MorrisNatschke, S

Lee, KH

机构：

[1] HIROSHIMA UNIV,FAC INTEGRATED ARTS & SCI,DEPT INTERDISCIPLINARY STUDIES NAT ENVIRONM,HIGASHIHIROSHIMA 739,JAPAN

[2] KOBE PHARMACEUT UNIV,FAC PHARMACEUT SCI,KOBE,HYOGO 658,JAPAN

[3] BIOTECH RES LABS INC,ROCKVILLE,MD 20850

[4] UNIV N CAROLINA,SCH MED,CHAPEL HILL,NC 27599

[5] UNIV N CAROLINA,SCH PHARM,DIV MED CHEM & NAT PROD,NAT PROD LAB,CHAPEL HILL,NC 27599

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 06期

关键词：

D O I：

10.1016/0960-894X(96)00096-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Eighteen quassinoid glycosides and nine known quassinoids were tested for inhibitory activity against HIV replication in H9 lymphocytic cells. Of the compounds tested, shinjulactone C (20) demonstrated the highest anti-HIV activity (EC(50) = 10.6 mu M) in the absence of cytotoxicity with a therapeutic index of >25.

引用

页码：701 / 706

页数：6

共 19 条

[1]

[Anonymous], STUD NAT PROD CHEM

[2]

CHANG RS, 1991, P SOC EXP BIOL MED, V197, P59

[3] ANTI-AIDS AGENTS .6. SALASPERMIC ACID, AN ANTI-HIV PRINCIPLE FROM TRIPTERYGIUM-WILFORDII, AND THE STRUCTURE-ACTIVITY CORRELATION WITH ITS RELATED-COMPOUNDS [J].

CHEN, K ;

KASHIWADA, Y ;

ZHANG, DC ;

HU, CQ ;

JIN, JQ ;

NOZAKI, H ;

KILKUSKIE, RE ;

TRAMONTANO, E ;

CHENG, YC ;

MCPHAIL, DR ;

MCPHAIL, AT ;

LEE, KH ;

SHI, Q .

JOURNAL OF NATURAL PRODUCTS, 1992, 55 (03) :340-346

[4]

CHEN K, 1992, J NAT PRODUCTS, V57, P88

[5] ANTI-AIDS AGENTS .11. BETULINIC ACID AND PLATANIC ACID AS ANTI-HIV PRINCIPLES FROM SYZIGIUM-CLAVIFLORUM, AND THE ANTI-HIV ACTIVITY OF STRUCTURALLY RELATED TRITERPENOIDS [J].

FUJIOKA, T ;

KASHIWADA, Y ;

KILKUSKIE, RE ;

COSENTINO, LM ;

BALLAS, LM ;

JIANG, JB ;

JANZEN, WP ;

CHEN, IS ;

LEE, KH .

JOURNAL OF NATURAL PRODUCTS, 1994, 57 (02) :243-247

[6] ANTITUMOR AGENTS .90. BRUCEANTINOSIDE-C, A NEW CYTO-TOXIC QUASSINOID GLYCOSIDE FROM BRUCEA-ANTIDYSENTERICA [J].

FUKAMIYA, N ;

OKANO, M ;

TAGAHARA, K ;

ARATANI, T ;

MURAMOTO, Y ;

LEE, KH .

JOURNAL OF NATURAL PRODUCTS, 1987, 50 (06) :1075-1079

[7] ANTITUMOR AGENTS .127. BRUCEOSIDE-C, A NEW CYTOTOXIC QUASSINOID GLUCOSIDE, AND RELATED-COMPOUNDS FROM BRUCEA-JAVA']JAVANICA [J].

FUKAMIYA, N ;

OKANO, M ;

MIYAMOTO, M ;

TAGAHARA, K ;

LEE, KH .

JOURNAL OF NATURAL PRODUCTS, 1992, 55 (04) :468-475

[8]

GUSTAFSON KR, 1992, AIDS ANTIVIRAL NATUR, P57

[9]

HASHIMOTO F, UNPUB BIOORG MED CHE

[10] PRELIMINARY EVIDENCE FOR INHIBITORY EFFECT OF GLYCYRRHIZIN ON HIV REPLICATION IN PATIENTS WITH AIDS [J].

HATTORI, T ;

IKEMATSU, S ;

KOITO, A ;

MATSUSHITA, S ;

MAEDA, Y ;

HADA, M ;

FUJIMAKI, M ;

TAKATSUKI, K .

ANTIVIRAL RESEARCH, 1989, 11 (5-6) :255-261

← 1 2 →