Mdm2 increases cellular invasiveness by binding to and stabilizing the Slug mRNA

被引：29

作者：

Jung, Chan-Hun ^{[1
]}

Kim, Jongdoo ^{[1
]}

Park, Jong Kuk ^{[1
]}

Hwang, Sang-Gu ^{[1
]}

Moon, Sung-Kwon ^{[2
]}

Kim, Wun-Jae ^{[3
]}

Um, Hong-Duck ^{[1
]}

机构：

[1] Korea Inst Radiol & Med Sci, Div Radiat Canc Biol, Seoul 139706, South Korea

[2] Chung Ang Univ, Sch Food Sci & Technol, Ansung, South Korea

[3] Chungbuk Natl Univ, Dept Urol, Coll Med, Cheongju, Chungbuk, South Korea

来源：

CANCER LETTERS | 2013年 / 335卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Mdm2; Slug; p53; Cancer; Invasion; ENDOTHELIAL GROWTH-FACTOR; P53; PROMOTES; CANCER; EXPRESSION; DEGRADATION; INVASION; SNAIL; GENE; ONCOPROTEIN;

D O I：

10.1016/j.canlet.2013.02.035

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mdm2 is an oncoprotein that induces the degradation of the tumor suppressor, p53. Here, we show that Mdm2 increases the mRNA levels of Slug by binding to and stabilizing the Slug mRNA. While this effect of Mdm2 was observed in both p53-null and p53-expressing cancer cells, it increased the protein levels of Slug only in the former cells. Mdm2 consistently induced Slug-dependent events, such as decreases in E-cadherin levels and increases in cellular invasiveness, only in p53-null cells. Therefore, the binding of Mdm2 to the Slug mRNA appears to provide a novel mechanism through which Mdm2 promotes tumor progression in a manner independent of the presence of p53. (c) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：270 / 277

页数：8

共 39 条

[21] Bcl-w promotes cell invasion by blocking the invasion-suppressing action of Bax
Kim, Eun Mi
Kim, Jongdoo
Park, Jong Kuk
Hwang, Sang-Gu
Kim, Wun-Jae
Lee, Won-Jae
Kang, Sang Won
Um, Hong-Duck
[J]. CELLULAR SIGNALLING, 2012, 24 (06) : 1163 - 1172
[22] Kubbutat MHG, 1999, CELL GROWTH DIFFER, V10, P87
[23] LADANYI M, 1993, CANCER RES, V53, P16
[24] Lukas J, 2001, CANCER RES, V61, P3212
[25] Meek DW, 2003, MOL CANCER RES, V1, P1017
[26] The p53 mRNA-Mdm2 interaction
Naski, Nadia
Gajjar, Madhavsai
Bourougaa, Karima
Malbert-Colas, Laurence
Fahraeus, Robin
Candeias, Marco M.
[J]. CELL CYCLE, 2009, 8 (01) : 31 - 34
[27] The snail superfamily of zinc-finger transcription factors
Nieto, MA
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (03) : 155 - 166
[28] Snail, ZEB and bHLH factors in tumour progression: an alliance against the epithelial phenotype?
Peinado, Hector
Olmeda, David
Cano, Amparo
[J]. NATURE REVIEWS CANCER, 2007, 7 (06) : 415 - 428
[29] MDM2 promotes cell motility and invasiveness through a RING-finger independent mechanism
Polanski, Radoslaw
Warburton, Hazel E.
Ray-Sinha, Arpita
Devling, Timothy
Pakula, Hubert
Rubbi, Carlos P.
Vlatkovic, Nikolina
Boyd, Mark T.
[J]. FEBS LETTERS, 2010, 584 (22) : 4695 - 4702
[30] The EMT regulator slug and lung carcinogenesis
Shih, Jin-Yuan
Yang, Pan-Chyr
[J]. CARCINOGENESIS, 2011, 32 (09) : 1299 - 1304

← 1 2 3 4 →