Mdm2 increases cellular invasiveness by binding to and stabilizing the Slug mRNA

被引：29

作者：

Jung, Chan-Hun ^{[1
]}

Kim, Jongdoo ^{[1
]}

Park, Jong Kuk ^{[1
]}

Hwang, Sang-Gu ^{[1
]}

Moon, Sung-Kwon ^{[2
]}

Kim, Wun-Jae ^{[3
]}

Um, Hong-Duck ^{[1
]}

机构：

[1] Korea Inst Radiol & Med Sci, Div Radiat Canc Biol, Seoul 139706, South Korea

[2] Chung Ang Univ, Sch Food Sci & Technol, Ansung, South Korea

[3] Chungbuk Natl Univ, Dept Urol, Coll Med, Cheongju, Chungbuk, South Korea

来源：

CANCER LETTERS | 2013年 / 335卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

Mdm2; Slug; p53; Cancer; Invasion; ENDOTHELIAL GROWTH-FACTOR; P53; PROMOTES; CANCER; EXPRESSION; DEGRADATION; INVASION; SNAIL; GENE; ONCOPROTEIN;

D O I：

10.1016/j.canlet.2013.02.035

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Mdm2 is an oncoprotein that induces the degradation of the tumor suppressor, p53. Here, we show that Mdm2 increases the mRNA levels of Slug by binding to and stabilizing the Slug mRNA. While this effect of Mdm2 was observed in both p53-null and p53-expressing cancer cells, it increased the protein levels of Slug only in the former cells. Mdm2 consistently induced Slug-dependent events, such as decreases in E-cadherin levels and increases in cellular invasiveness, only in p53-null cells. Therefore, the binding of Mdm2 to the Slug mRNA appears to provide a novel mechanism through which Mdm2 promotes tumor progression in a manner independent of the presence of p53. (c) 2013 Elsevier Ireland Ltd. All rights reserved.

引用

页码：270 / 277

页数：8

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