机构:
Baylor Coll Med, Dept Med, Sect Gastroenterol & Hepatol, Houston, TX 77030 USA
Michael E DeBakey VA Med Ctr, Ctr Innovat Effectiveness & Qual, Houston, TX USABaylor Coll Med, Dept Med, Sect Gastroenterol & Hepatol, Houston, TX 77030 USA
Mittal, Sahil
[1
,2
]
Kramer, Jennifer R.
论文数: 0引用数: 0
h-index: 0
机构:
Michael E DeBakey VA Med Ctr, Ctr Innovat Effectiveness & Qual, Houston, TX USA
Michael E DeBakey VA Med Ctr, Sect Gastroenterol & Hepatol, Sect Hlth Serv Res, Houston, TX USABaylor Coll Med, Dept Med, Sect Gastroenterol & Hepatol, Houston, TX 77030 USA
Kramer, Jennifer R.
[2
,3
]
Richardson, Peter
论文数: 0引用数: 0
h-index: 0
机构:
Michael E DeBakey VA Med Ctr, Ctr Innovat Effectiveness & Qual, Houston, TX USA
Michael E DeBakey VA Med Ctr, Sect Gastroenterol & Hepatol, Sect Hlth Serv Res, Houston, TX USABaylor Coll Med, Dept Med, Sect Gastroenterol & Hepatol, Houston, TX 77030 USA
Richardson, Peter
[2
,3
]
Thrift, Aaron P.
论文数: 0引用数: 0
h-index: 0
机构:
Baylor Coll Med, Dept Med, Sect Gastroenterol & Hepatol, Houston, TX 77030 USA
Baylor Coll Med, Dan L Duncan Comprehens Canc Ctr, Houston, TX 77030 USABaylor Coll Med, Dept Med, Sect Gastroenterol & Hepatol, Houston, TX 77030 USA
Thrift, Aaron P.
[1
,4
]
El-Serag, Hashem B.
论文数: 0引用数: 0
h-index: 0
机构:
Baylor Coll Med, Dept Med, Sect Gastroenterol & Hepatol, Houston, TX 77030 USA
Michael E DeBakey VA Med Ctr, Ctr Innovat Effectiveness & Qual, Houston, TX USA
Michael E DeBakey VA Med Ctr, Sect Gastroenterol & Hepatol, Sect Hlth Serv Res, Houston, TX USABaylor Coll Med, Dept Med, Sect Gastroenterol & Hepatol, Houston, TX 77030 USA
El-Serag, Hashem B.
[1
,2
,3
]
Kanwal, Fasiha
论文数: 0引用数: 0
h-index: 0
机构:
Baylor Coll Med, Dept Med, Sect Gastroenterol & Hepatol, Houston, TX 77030 USA
Michael E DeBakey VA Med Ctr, Ctr Innovat Effectiveness & Qual, Houston, TX USA
Michael E DeBakey VA Med Ctr, Sect Gastroenterol & Hepatol, Sect Hlth Serv Res, Houston, TX USABaylor Coll Med, Dept Med, Sect Gastroenterol & Hepatol, Houston, TX 77030 USA
Background & Aims: Cirrhosis related to chronic hepatitis B (CHB) is a major risk factor for hepatocellular carcinoma (HCC). The extent to which HCC occurs in U.S. in the absence of cirrhosis in CHB remains unclear. Methods: We identified CHB patients who were diagnosed with HCC in the national Veterans Administration (VA) between 2001 and 2013. We defined presence and absence of cirrhosis at the time of HCC diagnosis using explicit histological, radiological, endoscopic, and laboratory criteria. We used multivariable regression analysis to identify demographic and clinical characteristics associated with CHB-related HCC in the absence of cirrhosis. We also examined liver transplant-free survival in CHB-HCC patients with and without cirrhosis. Results: Among 8539 CHB patients, 317 developed HCC of whom 30 (9.5%) did not have any evidence of cirrhosis at the time of HCC diagnosis. Compared to HCC patients with cirrhosis, HCC patients without cirrhosis were more likely to be non-white (African American, OR = 6.78; 95% CI 2.05-22.4; Asian, OR 11.6, 95% CI 2.63-50.8), have a family history of HCC (OR 32.9, 95% CI 3.76-288), and hypertension (OR 3.15, 95% CI 1.02-9.75). There was no significant difference in the transplant-free survival between CHB-HCC patients with and without cirrhosis (hazard ratio 0.68, 95% CI 0.43-1.09). Conclusions: Fewer than 10% of U.S. based CHB-related HCC patients did not have cirrhosis. Race and family history of HCC were the main risk factors for HCC in the absence of cirrhosis in CHB. These factors may help guide the decision to initiate HCC surveillance in CHB patients without cirrhosis. Lay summary: Patients with chronic hepatitis B who are African American, or Asian, older than 40 years of age with family members with liver cancer or high blood pressure are at a higher risk of developing liver cancer in the absence of cirrhosis. These patients should be included in the screening program for liver cancer. (C) 2016 European Association for the Study of the Liver. Published by Elsevier B.V. All rights reserved.
机构:
Stanford Univ, Med Ctr, Dept Med, Palo Alto, CA 94304 USAStanford Univ, Med Ctr, Dept Med, Palo Alto, CA 94304 USA
Chen, Vincent L.
;
Le, An K.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Med Ctr, Div Gastroenterol & Hepatol, 750 Welch Rd,Suite 210, Palo Alto, CA 94304 USAStanford Univ, Med Ctr, Dept Med, Palo Alto, CA 94304 USA
Le, An K.
;
Kim, Nathan G.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Stanford, CA 94305 USAStanford Univ, Med Ctr, Dept Med, Palo Alto, CA 94304 USA
Kim, Nathan G.
;
Kim, Lily H.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Med Ctr, Div Gastroenterol & Hepatol, 750 Welch Rd,Suite 210, Palo Alto, CA 94304 USA
Stanford Univ, Sch Med, Stanford, CA 94305 USAStanford Univ, Med Ctr, Dept Med, Palo Alto, CA 94304 USA
Kim, Lily H.
;
Nguyen, Nghia H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Med, San Diego, CA 92103 USAStanford Univ, Med Ctr, Dept Med, Palo Alto, CA 94304 USA
Nguyen, Nghia H.
;
Nguyen, Pauline P.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Med Ctr, Div Gastroenterol & Hepatol, 750 Welch Rd,Suite 210, Palo Alto, CA 94304 USAStanford Univ, Med Ctr, Dept Med, Palo Alto, CA 94304 USA
Nguyen, Pauline P.
;
Zhao, Changqing
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Med Ctr, Div Gastroenterol & Hepatol, 750 Welch Rd,Suite 210, Palo Alto, CA 94304 USA
Shanghai Univ TCM, Shuguang Hosp, Inst Liver Dis, Dept Cirrhosis, Shanghai, Peoples R ChinaStanford Univ, Med Ctr, Dept Med, Palo Alto, CA 94304 USA
Zhao, Changqing
;
Nguyen, Mindie H.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Med Ctr, Div Gastroenterol & Hepatol, 750 Welch Rd,Suite 210, Palo Alto, CA 94304 USAStanford Univ, Med Ctr, Dept Med, Palo Alto, CA 94304 USA
机构:
Stanford Univ, Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USAStanford Univ, Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USA
Do, Ailinh L.
;
Wong, Carrie R.
论文数: 0引用数: 0
h-index: 0
机构:
Pacific Hlth Fdn, San Jose, CA USAStanford Univ, Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USA
Wong, Carrie R.
;
Nguyen, Long H.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USAStanford Univ, Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USA
Nguyen, Long H.
;
Nguyen, Vincent G.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USA
Pacific Hlth Fdn, San Jose, CA USAStanford Univ, Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USA
Nguyen, Vincent G.
;
Huy Trinh
论文数: 0引用数: 0
h-index: 0
机构:
Pacific Hlth Fdn, San Jose, CA USA
San Jose Gastroenterol, San Jose, CA USAStanford Univ, Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USA
Huy Trinh
;
Nguyen, Mindie H.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USAStanford Univ, Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USA
机构:
Michael E DeBakey VA Med Ctr, Sect Gastroenterol & Hepatol, Dept Med, Houston, TX USA
Baylor Coll Med, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Sect Gastroenterol & Hepatol, Dept Med, Houston, TX USA
机构:
Stanford Univ, Med Ctr, Dept Med, Palo Alto, CA 94304 USAStanford Univ, Med Ctr, Dept Med, Palo Alto, CA 94304 USA
Chen, Vincent L.
;
Le, An K.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Med Ctr, Div Gastroenterol & Hepatol, 750 Welch Rd,Suite 210, Palo Alto, CA 94304 USAStanford Univ, Med Ctr, Dept Med, Palo Alto, CA 94304 USA
Le, An K.
;
Kim, Nathan G.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Stanford, CA 94305 USAStanford Univ, Med Ctr, Dept Med, Palo Alto, CA 94304 USA
Kim, Nathan G.
;
Kim, Lily H.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Med Ctr, Div Gastroenterol & Hepatol, 750 Welch Rd,Suite 210, Palo Alto, CA 94304 USA
Stanford Univ, Sch Med, Stanford, CA 94305 USAStanford Univ, Med Ctr, Dept Med, Palo Alto, CA 94304 USA
Kim, Lily H.
;
Nguyen, Nghia H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Diego, Dept Med, San Diego, CA 92103 USAStanford Univ, Med Ctr, Dept Med, Palo Alto, CA 94304 USA
Nguyen, Nghia H.
;
Nguyen, Pauline P.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Med Ctr, Div Gastroenterol & Hepatol, 750 Welch Rd,Suite 210, Palo Alto, CA 94304 USAStanford Univ, Med Ctr, Dept Med, Palo Alto, CA 94304 USA
Nguyen, Pauline P.
;
Zhao, Changqing
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Med Ctr, Div Gastroenterol & Hepatol, 750 Welch Rd,Suite 210, Palo Alto, CA 94304 USA
Shanghai Univ TCM, Shuguang Hosp, Inst Liver Dis, Dept Cirrhosis, Shanghai, Peoples R ChinaStanford Univ, Med Ctr, Dept Med, Palo Alto, CA 94304 USA
Zhao, Changqing
;
Nguyen, Mindie H.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Med Ctr, Div Gastroenterol & Hepatol, 750 Welch Rd,Suite 210, Palo Alto, CA 94304 USAStanford Univ, Med Ctr, Dept Med, Palo Alto, CA 94304 USA
机构:
Stanford Univ, Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USAStanford Univ, Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USA
Do, Ailinh L.
;
Wong, Carrie R.
论文数: 0引用数: 0
h-index: 0
机构:
Pacific Hlth Fdn, San Jose, CA USAStanford Univ, Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USA
Wong, Carrie R.
;
Nguyen, Long H.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USAStanford Univ, Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USA
Nguyen, Long H.
;
Nguyen, Vincent G.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USA
Pacific Hlth Fdn, San Jose, CA USAStanford Univ, Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USA
Nguyen, Vincent G.
;
Huy Trinh
论文数: 0引用数: 0
h-index: 0
机构:
Pacific Hlth Fdn, San Jose, CA USA
San Jose Gastroenterol, San Jose, CA USAStanford Univ, Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USA
Huy Trinh
;
Nguyen, Mindie H.
论文数: 0引用数: 0
h-index: 0
机构:
Stanford Univ, Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USAStanford Univ, Med Ctr, Div Gastroenterol & Hepatol, Palo Alto, CA 94304 USA
机构:
Michael E DeBakey VA Med Ctr, Sect Gastroenterol & Hepatol, Dept Med, Houston, TX USA
Baylor Coll Med, Houston, TX 77030 USAMichael E DeBakey VA Med Ctr, Sect Gastroenterol & Hepatol, Dept Med, Houston, TX USA