In vitro activity of EDTA and TOL-463 against Neisseria gonorrhoeae

被引：4
作者：
Nash, Evelyn E. [1 ]
Henning, Tara C. [1 ]
Pham, Cau D. [1 ]
Pettus, Kevin [1 ]
Sharpe, Samera [1 ]
Kersh, Ellen N. [1 ]
机构：
[1] Ctr Dis Control & Prevent, Div Sexually Transmitted Dis Prevent, US Dept Hlth & Human Serv, Atlanta, GA 30333 USA
来源：
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE | 2019年 / 93卷 / 04期
关键词：
Neisseria gonorrhoeae; Antimicrobial resistance; EDTA; Boric acid; Broth microdilution; MULTIDRUG-RESISTANT; DRUG-RESISTANT; MECHANISMS; EXPOSURE; THERAPY;
D O I：
10.1016/j.diagmicrobio.2018.10.021
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
Neisseria gonorrhoeae quickly develops drug resistance. Time-kill curves revealed that EDTA and TOL-463 inhibit growth similar to penicillin, ciprofloxacin, and azithromycin. Furthermore, synergistic and additive antimicrobial interactions occurred when EDTA and TOL-463 were combined with penicillin or azithromycin, respectively, suggesting that further investigations into these unconventional antimicrobials may be advantageous. (C) 2018 Elsevier Inc. All rights reserved.
引用
收藏
页码：369 / 371
页数：3
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