Ultra-small NLC for improved dermal delivery of coenyzme Q10

被引：59
|
作者：
Schwarz, Julia C. [1 ]
Baisaeng, Nuttakorn [2 ]
Hoppel, Magdalena [1 ]
Loew, Monika [3 ]
Keck, Cornelia M. [4 ]
Valenta, Claudia [1 ,3 ]
机构：
[1] Univ Vienna, A-1090 Vienna, Austria
[2] Free Univ Berlin, Inst Pharm Pharmazeut Technol Biopharm & Kosmet, D-12169 Berlin, Germany
[3] Univ Vienna, Fac Life Sci, Dept Pharmaceut Technol & Biopharmaceut, A-1090 Vienna, Austria
[4] Univ Appl Sci Kaiserslautern, Appl Pharm Div, D-66953 Pirmasens, Germany
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 2013年 / 447卷 / 1-2期
关键词：
NLC; Nanoemulsion; Coenzyme Q10; Skin permeation; Stability; SOLID LIPID NANOPARTICLES; COENZYME Q(10); CARRIERS NLC; SKIN; PENETRATION; UBIQUINONE; NANOEMULSIONS; PEROXIDATION; PRODUCTS; RELEASE;
D O I：
10.1016/j.ijpharm.2013.02.037
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Coenzyme Q10 (CoQ10) acts as an antioxidant in the skin and is frequently contained in anti-aging products. In previous studies, it could be shown that nano-structured lipid carriers (NLC) with a size of about 230 nm are beneficial for the dermal delivery of CoQ10. They increased Q10 skin penetration when compared to equally sized nanoemulsion. In this study, ultra-small NLC were prepared with even smaller mean particles sizes of around 80 nm. The influence of this decrease of particle size was investigated in terms of skin permeation and penetration as well as physicochemical stability of the NLC. Improved dermal delivery of CoQ10 by ultra-small NLC could be achieved. (C) 2013 Elsevier B. V. All rights reserved.
引用
收藏
页码：213 / 217
页数：5
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