Novel chelate-setting calcium-phosphate cements fabricated with wet-synthesized hydroxyapatite powder

被引：9

作者：

Konishi, Toshiisa ^{[1
,2
]}

Horiguchi, Yukiko ^{[3
]}

Mizumoto, Minori ^{[1
]}

Honda, Michiyo ^{[1
]}

Oribe, Kazuya ^{[3
]}

Morisue, Hikaru ^{[4
]}

Ishii, Ken ^{[1
,4
]}

Toyama, Yoshiaki ^{[4
]}

Matsumoto, Morio ^{[1
,4
]}

Aizawa, Mamoru ^{[1
,2
]}

机构：

[1] KAST, Takatsu Ku, Kawasaki, Kanagawa 2130012, Japan

[2] Meiji Univ, Dept Appl Chem, Sch Sci & Technol, Tama Ku, Kawasaki, Kanagawa 2148571, Japan

[3] Showa Ika Kohgyo Co Ltd, Toyohashi, Aichi 4418571, Japan

[4] Keio Univ, Dept Orthopaed Surg, Sch Med, Shinjuku Ku, Tokyo 1608582, Japan

来源：

JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2013年 / 24卷 / 03期

关键词：

MECHANICAL-PROPERTIES; COMPRESSIVE STRENGTH; CERAMICS; POROSITY; SIZES; KINDS;

D O I：

10.1007/s10856-012-4834-9

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

The hydroxyapatite (HAp) powder preparation process was optimized to fabricate inositol phosphate-HAp (IP6-HAp) cement with enhanced mechanical properties. Starting HAp powders were synthesized via a wet chemical process. The effect of the powder preparation process on the morphology, crystallinity, median particle size, and specific surface area (SSA) of the cement powders was examined, together with the mechanical properties of the resulting cement specimens. The smallest crystallite and median particle sizes, and the highest SSA were obtained from ball-milling of as-synthesized HAp powder under wet conditions and then freeze-drying. IP6-HAp cement fabricated with this powder had a maximum compressive strength of 23.1 +/- A 2.1 MPa. In vivo histological studies using rabbit models revealed that the IP6-HAp cements were directly in contact with newly formed and host bones. Thus, the present chelate-setting HAp cement is promising for application as a novel paste-like artificial bone.

引用

页码：611 / 621

页数：11

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