Neurolymphomatosis is defined as infiltration of the nervous system by hematological malignancy and is difficult to diagnose. We report a case of a 57-year-old man, treated for small B-cell non-Hodgkin lymphoma, presenting with sensorimotor impairment of the lower limbs, which started 6 years after diagnosis. He was treated with chemotherapy, after which, the symptoms disappeared. After 7 months, he developed sensorimotor impairment of both upper limbs. MRI of the brachial plexus showed no abnormalities. F-18-FDG PET-CT showed increased uptake at the brachial plexus and nerves, suggesting neurolymphomatosis. Confirmatory biopsy revealed conversion of the malignancy to diffuse large B-cell lymphoma.
机构:
Hadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Hadassah Hebrew Univ Med Ctr, Dept Hematol, IL-91120 Jerusalem, IsraelHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Grisariu, Sigal
;
Avni, Batia
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Hadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Hadassah Hebrew Univ Med Ctr, Dept Hematol, IL-91120 Jerusalem, IsraelHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Avni, Batia
;
Batchelor, Tracy T.
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Massachusetts Gen Hosp, Ctr Canc, Boston, MA USAHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Batchelor, Tracy T.
;
van den Bent, Martin J.
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Erasmus Univ, Med Ctr, Neurooncol Unit, Dr Daniel Den Hoed Canc Ctr, Rotterdam, NetherlandsHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
van den Bent, Martin J.
;
Bokstein, Felix
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Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Oncol, IL-69978 Tel Aviv, IsraelHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Bokstein, Felix
;
Schiff, David
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Univ Virginia, Neurooncol Ctr, Charlottesville, VA USAHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Schiff, David
;
Kuittinen, Outi
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Oulu Univ Hosp, Dept Oncol, Oulu, FinlandHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Kuittinen, Outi
;
Chamberlain, Marc C.
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Univ Washington, Dept Neurol, Seattle, WA 98195 USAHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Chamberlain, Marc C.
;
Roth, Patrick
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Univ Zurich Hosp, Dept Neurol, CH-8091 Zurich, SwitzerlandHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Roth, Patrick
;
Nemets, Anatoly
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Barzilai Govt Hosp, Dept Hematol, Ashqelon, IsraelHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Nemets, Anatoly
;
Shalom, Edna
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Hadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Hadassah Hebrew Univ Med Ctr, Dept Hematol, IL-91120 Jerusalem, IsraelHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Shalom, Edna
;
Ben-Yehuda, Dina
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Hadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Hadassah Hebrew Univ Med Ctr, Dept Hematol, IL-91120 Jerusalem, IsraelHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Ben-Yehuda, Dina
;
Siegal, Tali
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机构:
Hadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Hadassah Hebrew Univ Med Ctr, Dept Hematol, IL-91120 Jerusalem, IsraelHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
机构:
Hadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Hadassah Hebrew Univ Med Ctr, Dept Hematol, IL-91120 Jerusalem, IsraelHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Grisariu, Sigal
;
Avni, Batia
论文数: 0引用数: 0
h-index: 0
机构:
Hadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Hadassah Hebrew Univ Med Ctr, Dept Hematol, IL-91120 Jerusalem, IsraelHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Avni, Batia
;
Batchelor, Tracy T.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Ctr Canc, Boston, MA USAHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Batchelor, Tracy T.
;
van den Bent, Martin J.
论文数: 0引用数: 0
h-index: 0
机构:
Erasmus Univ, Med Ctr, Neurooncol Unit, Dr Daniel Den Hoed Canc Ctr, Rotterdam, NetherlandsHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
van den Bent, Martin J.
;
Bokstein, Felix
论文数: 0引用数: 0
h-index: 0
机构:
Tel Aviv Univ, Tel Aviv Sourasky Med Ctr, Dept Oncol, IL-69978 Tel Aviv, IsraelHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Bokstein, Felix
;
Schiff, David
论文数: 0引用数: 0
h-index: 0
机构:
Univ Virginia, Neurooncol Ctr, Charlottesville, VA USAHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Schiff, David
;
Kuittinen, Outi
论文数: 0引用数: 0
h-index: 0
机构:
Oulu Univ Hosp, Dept Oncol, Oulu, FinlandHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Kuittinen, Outi
;
Chamberlain, Marc C.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Dept Neurol, Seattle, WA 98195 USAHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Chamberlain, Marc C.
;
Roth, Patrick
论文数: 0引用数: 0
h-index: 0
机构:
Univ Zurich Hosp, Dept Neurol, CH-8091 Zurich, SwitzerlandHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Roth, Patrick
;
Nemets, Anatoly
论文数: 0引用数: 0
h-index: 0
机构:
Barzilai Govt Hosp, Dept Hematol, Ashqelon, IsraelHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Nemets, Anatoly
;
Shalom, Edna
论文数: 0引用数: 0
h-index: 0
机构:
Hadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Hadassah Hebrew Univ Med Ctr, Dept Hematol, IL-91120 Jerusalem, IsraelHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Shalom, Edna
;
Ben-Yehuda, Dina
论文数: 0引用数: 0
h-index: 0
机构:
Hadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Hadassah Hebrew Univ Med Ctr, Dept Hematol, IL-91120 Jerusalem, IsraelHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Ben-Yehuda, Dina
;
Siegal, Tali
论文数: 0引用数: 0
h-index: 0
机构:
Hadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel
Hadassah Hebrew Univ Med Ctr, Dept Hematol, IL-91120 Jerusalem, IsraelHadassah Hebrew Univ Med Ctr, Gaffin Ctr Neurooncol, IL-91120 Jerusalem, Israel