Clinical Features and Treatment Outcomes of Vitreoretinal Lymphoma according to Its Association with CNS Lymphoma

被引：40
作者：
Cho, Bum-Joo [1 ,2 ]
Kim, Dong Yoon [3 ]
Park, Un Chul [2 ]
Lee, Joo Yong [3 ]
Yoon, Young Hee [3 ]
Yu, Hyeong Gon [2 ]
机构：
[1] Hallym Univ, Coll Med, Chuncheon Sacred Heart Hosp, Dept Ophthalmol, Chunchon, South Korea
[2] Seoul Natl Univ, Coll Med, Dept Ophthalmol, Seoul Natl Univ Hosp, Seoul, South Korea
[3] Univ Ulsan, Dept Ophthalmol, Coll Med, Asan Med Ctr, Seoul, South Korea
来源：
OCULAR IMMUNOLOGY AND INFLAMMATION | 2018年 / 26卷 / 03期
关键词：
CNS lymphoma; diffuse large B-cell lymphoma; intraocular lymphoma; overall survival; vitreoretinal lymphoma; PRIMARY INTRAOCULAR LYMPHOMA; NERVOUS-SYSTEM LYMPHOMA; COLLABORATIVE GROUP-REPORT; THERAPY; METHOTREXATE; INVOLVEMENT; DIAGNOSIS;
D O I：
10.1080/09273948.2017.1421669
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Purpose: To compare the clinical features and treatment outcomes of different types of vitreoretinal lymphoma (VRL) that presents primarily, secondarily, or concurrently in association with CNS lymphoma.Methods: We retrospectively reviewed the medical records of 53 patients with VRL pathologically confirmed between 2000 and 2014 in two of the largest tertiary hospitals in Korea.Results: The proportions of primary, secondary, and concurrent VRL were 26%, 34%, and 40%, respectively. The primary VRL group had retinal infiltration most frequently (68%) among all groups and presented with the worst visual acuity at diagnosis (P=0.035). The diagnostic delay was significantly shorter in patients with secondary VRL (1.4months; P<0.001). Median overall survival was 31months in the entire cohort, and it was shortest in the concurrent VRL/CNS lymphoma group (18months; P=0.007).Conclusions: Ocular presentation and survival times may be different in VRL patients according to the association with CNS involvement.
引用
收藏
页码：365 / 371
页数：7
相关论文
共 23 条
[1]   Intraocular-central nervous system lymphoma - Clinical features, diagnosis, and outcomes [J].
Akpek, EK ;
Ahmed, I ;
Hochberg, FH ;
Soheilian, M ;
Dryja, TP ;
Jakobiec, FA ;
Foster, CS .
OPHTHALMOLOGY, 1999, 106 (09) :1805-1810
[2]  
Aronow Mary E, 2012, Int Ophthalmol Clin, V52, P199, DOI 10.1097/IIO.0b013e318265d4e3
[3]  
Batchelor TT, 2003, CLIN CANCER RES, V9, P711
[4]   Primary Vitreoretinal Lymphoma: A Report from an International Primary Central Nervous System Lymphoma Collaborative Group Symposium [J].
Chan, Chi-Chao ;
Rubenstein, James L. ;
Coupland, Sarah E. ;
Davis, Janet L. ;
Harbour, J. William ;
Johnston, Patrick B. ;
Cassoux, Nathalie ;
Touitou, Valerie ;
Smith, Justine R. ;
Batchelor, Tracy T. ;
Pulido, Jose S. .
ONCOLOGIST, 2011, 16 (11) :1589-1599
[5]   Intensive chemoimmunotherapy and bilateral globe irradiation as initial therapy for primary intraocular lymphoma [J].
Cheah, Chan Yoon ;
Milgrom, Sarah ;
Chihara, Dai ;
Gombos, Dan S. ;
Pinnix, Chelsea C. ;
Dabaja, Bouthaina S. ;
Fowler, Nathan H. .
NEURO-ONCOLOGY, 2016, 18 (04) :575-581
[6]   Intravitreal methotrexate for treating vitreoretinal lymphoma: 10 years of experience [J].
Frenkel, S. ;
Hendler, K. ;
Siegal, T. ;
Shalom, E. ;
Pe'er, J. .
BRITISH JOURNAL OF OPHTHALMOLOGY, 2008, 92 (03) :383-388
[7]   Primary CNS lymphoma with intraocular involvement International PCNSL Collaborative Group Report [J].
Grimm, S. A. ;
McCannel, C. A. ;
Omuro, A. M. P. ;
Ferreri, A. J. M. ;
Blay, J. -Y. ;
Neuwelt, E. A. ;
Siegal, T. ;
Batchelor, T. ;
Jahnke, K. ;
Shenkier, T. N. ;
Hall, A. J. ;
Graus, F. ;
Herrlinger, U. ;
Schiff, D. ;
Raizer, J. ;
Rubenstein, J. ;
Laperriere, N. ;
Thiel, E. ;
Doolittle, N. ;
Iwamoto, F. M. ;
Abrey, L. E. .
NEUROLOGY, 2008, 71 (17) :1355-1360
[8]   Primary intraocular lymphoma: an international primary central nervous system lymphoma collaborative group report [J].
Grimm, S. A. ;
Pulido, J. S. ;
Jahnke, K. ;
Schiff, D. ;
Hall, A. J. ;
Shenkier, T. N. ;
Siegal, T. ;
Doolittle, N. D. ;
Batchelor, T. ;
Herrlinger, U. ;
Neuwelt, E. A. ;
Laperriere, N. ;
Chamberlain, M. C. ;
Blay, J. Y. ;
Ferreri, A. J. M. ;
Omuro, A. M. P. ;
Thiel, E. ;
Abrey, L. E. .
ANNALS OF ONCOLOGY, 2007, 18 (11) :1851-1855
[9]   Association between ocular findings and preventive therapy with onset of central nervous system involvement in patients with primary vitreoretinal lymphoma [J].
Hashida, Noriyasu ;
Nakai, Kei ;
Saitoh, Norimitsu ;
Nishida, Kohji .
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, 2014, 252 (04) :687-693
[10]   Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop [J].
Jabs, DA ;
Nussenblatt, RB ;
Rosenbaum, JT .
AMERICAN JOURNAL OF OPHTHALMOLOGY, 2005, 140 (03) :509-516
123