Phosphate deprivation is associated with high resistance to latamoxef of gel-entrapped, sessile-like Escherichia coli cells

被引:15
|
作者
Vilain, S [1 ]
Cosette, P [1 ]
Junter, GA [1 ]
Jouenne, T [1 ]
机构
[1] Fac Sci Rouen, IFRMP 23, CNRS, UMR 6522, F-76821 Mont St Aignan, France
关键词
D O I
10.1093/jac/49.2.315
中图分类号
R51 [传染病];
学科分类号
100401 ;
摘要
Viable Escherichia coli cells were entrapped in agar gel layers and incubated in a phosphate-limited glucose medium. Immobilized bacteria displayed enhanced alkaline phosphatase activity and overexpressed the outer membrane protein PhoE as compared with free-floating organisms. These observations highlighted the existence of high phosphate deprivation within biofilm-like structures. In addition, the antimicrobial efficacy of latamoxef against immobilized bacteria was partly recovered in the presence of a high phosphate concentration. From these data, a possible role of phosphate deprivation in the high resistance of sessile-like organisms to antibiotics may be considered.
引用
收藏
页码:315 / 320
页数:6
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