Herpes simplex type 2 encephalitis and methotrexate medication: a fortuitous or causative association in a patient with spondyloarthritis?

被引：1
作者：
Lupo, Julien [1 ,2 ]
Dos Santos, Ophelie [3 ]
Germi, Raphaele [1 ,2 ]
Baccard-Longere, Monique [1 ]
Stahl, Jean-Paul [3 ]
Epaulard, Olivier [3 ]
Morand, Patrice [1 ,2 ]
机构：
[1] Univ Hosp Grenoble, Lab Virol, Grenoble, France
[2] Univ Grenoble Alpes, CNRS, CEA, Inst Biol Struct, Grenoble, France
[3] Univ Hosp Grenoble, Infect Dis Dept, Grenoble, France
来源：
ANTIVIRAL THERAPY | 2017年 / 22卷 / 04期
关键词：
CENTRAL-NERVOUS-SYSTEM; LOW-DOSE METHOTREXATE; EPSTEIN-BARR-VIRUS; RHEUMATOID-ARTHRITIS; CEREBROSPINAL-FLUID; INFECTIONS; MANIFESTATIONS; DIAGNOSIS; SAMPLES; RISK;
D O I：
10.3851/IMP3110
中图分类号：
R51 [传染病];
学科分类号：
100401 ;
摘要：
It is unclear whether immunosuppression is a risk factor for herpes encephalitis. Herein, we describe a rare case of herpes simplex virus type 2 encephalitis in a patient treated with low-dose methotrexate for HLA-B27-associated spondyloarthritis. The patient was successfully treated with acyclovir but presented sequelae of encephalitis. Here we discuss the possible role of low-dose methotrexate therapy as a risk factor of neurological herpes reactivation and severe disease. The host-related and viral risk factors are also addressed.
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收藏
页码：357 / 359
页数：3
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