Sodium nitroprusside selectively induces apoptotic cell death in the outer retina of the rat

被引：20

作者：

Ju, WK ^{[1
]}

Chung, IW ^{[1
]}

Kim, KY ^{[1
]}

Gwon, JS ^{[1
]}

Lee, MY ^{[1
]}

Oh, SJ ^{[1
]}

Chun, MH ^{[1
]}

机构：

[1] Catholic Univ Korea, Coll Med, Dept Anat, Seoul 137701, South Korea

来源：

NEUROREPORT | 2001年 / 12卷 / 18期

关键词：

apoptosis; necrosis; nitric oxide; rat; retina; sodium nitroprusside;

D O I：

10.1097/00001756-200112210-00043

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Sodium nitroprusside (SNP), an NO donor, was studied for its effects on apoptosis in rat retinal neurons. TUNEL-positive cells were observed in the outer nuclear layer (ONL), but not in the inner retina after SNP treatment. Inner retinal neurons died by necrosis. No photoreceptor cells were found in the ONL after seven days. Immunoblotting confirmed that neurnal NO synthase expression increased up to 5 days (similar to 170% of control levels), and then declined by 7 days, suggesting that NO induces apoptosis in the ONL, and that inner retinal neurons die by necrosis due to glutamate from damaged photoreceptors. NeuroReport 12:4075-4079 (C) 2001 Lippincott Williams & Wilkins.

引用

页码：4075 / 4079

页数：5

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