The NS1 Protein of Influenza A Virus Blocks RIG-I-Mediated Activation of the Noncanonical NF-κB Pathway and p52/RelB-Dependent Gene Expression in Lung Epithelial Cells

被引：61

作者：

Rueckle, Andrea ^{[1
]}

Haasbach, Emanuel ^{[2
]}

Julkunen, Ilkka ^{[3
]}

Planz, Oliver ^{[2
]}

Ehrhardt, Christina ^{[1
]}

Ludwig, Stephan ^{[1
]}

机构：

[1] Univ Munster, Ctr Mol Biol Inflammat ZMBE, IMV, D-4400 Munster, Germany

[2] Univ Tubingen, Dept Immunol, Interfac Inst Cell Biol, Tubingen, Germany

[3] Natl Inst Hlth & Welf THL, Virol Unit, Helsinki, Finland

来源：

JOURNAL OF VIROLOGY | 2012年 / 86卷 / 18期

关键词：

IKK-ALPHA; SIGNALING PATHWAY; BETA-INTERFERON; TARGET GENES; KINASE-ALPHA; INDUCTION; PREREQUISITE; RECOGNITION; LYMPHOTOXIN; DEFICIENT;

D O I：

10.1128/JVI.00323-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Influenza A virus (IAV) infection of epithelial cells activates NF-kappa B transcription factors via the canonical NF-kappa B signaling pathway, which modulates both the antiviral immune response and viral replication. Since almost nothing is known so far about a function of noncanonical NF-kappa B signaling after IAV infection, we tested infected cells for activation of p52 and RelB. We show that the viral NS1 protein strongly inhibits RIG-I-mediated noncanonical NF-kappa B activation and expression of the noncanonical target gene CCL19.

引用

页码：10211 / 10217

页数：7

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