Copper-64 labelling of triazacyclononane-triphosphinate chelators

被引：26

作者：

Simecek, Jakub ^{[1
]}

Wester, Hans-Juergen ^{[1
]}

Notni, Johannes ^{[1
]}

机构：

[1] Tech Univ Munich, D-85748 Garching, Germany

来源：

DALTON TRANSACTIONS | 2012年 / 41卷 / 45期

关键词：

GA-68; PET; COMPLEXES; LIGANDS; RADIOPHARMACEUTICALS; CU-64; TRAP; ACID;

D O I：

10.1039/c2dt31880f

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

The 1,4,7-triazacyclononane-1,4,7-tris(methylenephosphinic acid) chelators TRAP and NOPO are complexing copper-64 with similar efficiency as 1,4,7-triazacyclononane- triacetic acid (NOTA). The kinetic stability of Cu-64-labelled TRAP-peptides is sufficient for PET imaging at early time points (1-2 h post injection). For labelling of TRAP conjugates, Cu-64 can be recommended as an alternative to Ga-68 to achieve higher resolution of PET images.

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收藏

页码：13803 / 13806

页数：4

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