Trabecular Meshwork in Normal and Pathological Eyes

被引:24
|
作者
Pescosolido, Nicola [1 ]
Cavallotti, Carlo [2 ]
Rusciano, Dario [3 ]
Nebbioso, Marcella [4 ]
机构
[1] Univ Roma La Sapienza, Dept Sci Cardiovasc Resp & Morphol Sci, Rome, Italy
[2] Univ Roma La Sapienza, Dept Human Anat, Rome, Italy
[3] Sooft Italia Spa, Montegiorgio, Italy
[4] Univ Roma La Sapienza, Dept Sense Organs, Ctr Ocular Electrophysiol, Rome, Italy
关键词
Glycosaminoglycans; iridocorneal angle; mucopolysaccharides; primary open angle glaucoma; proteoglycans; OPEN-ANGLE GLAUCOMA; AGE-RELATED-CHANGES; CHONDROITIN SULFATE; HYALURONIC-ACID; RABBIT EYE; GLYCOSAMINOGLYCANS; DEXAMETHASONE; PROTEOGLYCANS; ANTERIOR; GAGS;
D O I
10.3109/01913123.2011.634090
中图分类号
TH742 [显微镜];
学科分类号
摘要
Purpose: The impact of glycosaminoglycans on intraocular pressure in glaucoma patients and in healthy young or aging subjects is explored. Materials and Methods: Thirty small autoptic samples were harvested from the tissue localized around the iridocorneal angle of the eye, taking care not to cause aesthetic damage. The samples came from three groups (young, old, and subjects with glaucoma). All samples were divided in two fragments and both were used for morphological and biochemical analyses. Quantitative data were obtained from image analysis to correlate with biochemical values. All results were statistically analyzed. Results: The findings show the following changes of iridocorneal angle are caused by glycosaminoglycans both in aging and in glacoumatous patients: (1) deposition of fibrous granular material and increased electron density of the structures close to the iridocorneal angle; and (2) strong decrease of hyaluronic acid content and increase of sulfated glycosaminoglycans. Conclusions: Similar to what happens in other tissues in the body, glycosaminoglycans of the human iridocorneal angle undergo physiological and pathological changes. The trabecular meshwork is the structure responsible for the regulation of the aqueous humor outflow that is often altered in primary open-angle glaucoma patients.
引用
收藏
页码:102 / 107
页数:6
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