Three male patients with sporadic acute hepatitis E in Sendai, Japan, who were domestically infected with hepatitis E virus of genotype III or IV

被引:19
|
作者
Yamamoto, T
Suzuki, H
Toyota, T
Takahashi, M
Okamoto, H
机构
[1] Tohoku Rosai Hosp, Dept Hepatol, Aoba Ku, Sendai, Miyagi 9818563, Japan
[2] Shiogama City Hosp, Dept Internal Med, Shiogama, Miyagi, Japan
[3] Jichi Med Sch, Dept Infect & Immun, Div Virol, Minami Kawachi, Tochigi, Japan
关键词
acute hepatitis E; domestic infection; genotype; hepatitis E virus; phylogenetic tree;
D O I
10.1007/s00535-003-1292-7
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
Recent studies indicate that hepatitis E virus (HEV) infection occurs not only in developing countries but also in industrialized nations. However, the characteristics of domestic infections of hepatitis E in Japan are not fully understood. We analyzed serum samples from 34 patients who were seen at a city hospital in Sendai, Japan, between January 1997 and December 2002, and who had been given the diagnosis of sporadic acute hepatitis of non-A, non-B, non-C etiology. Among these 34 patients, 3 (9%; all men; aged 54, 59, and 61 years) were positive for both IgG and IgM anti-HEV antibodies and for HEV RNA. The HEV isolates (HE-JASI and HE-JAS3) obtained from case 1 and case 3, respectively, segregated into genotype III; they had the highest nucleotide sequence identity, of 99.5% and 99.0%, with HE-JA7 and HE-JA8, respectively, both of which had been isolated in Iwate, a neighboring prefecture of Sendai. In contrast, the remaining HEV isolate (HE-JAS2), obtained from case 2, segregated into genotype IV; it had the highest nucleotide sequence identity, of 99.8% and 99.3%, with JKK-Sap and HE-JA3, respectively, both of which had been isolated in Hokkaido, Japan, although case 2 had never been to Hokkaido. Our three patients with hepatitis E had not traveled abroad in the preceding 1 year, had had no contact with pigs, and no history of blood transfusion. These results indicate that HEV should be considered as an etiological agent of acute hepatitis of non-A, non-B, non-C etiology in Japan. The risk factor(s) for acquiring domestic HEV infection in Japan needs to be clarified in future studies.
引用
收藏
页码:292 / 298
页数:7
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