Overexpression of thymic stromal lymphopoietin in allergic rhinitis

被引：81
作者：
Mou, Zhonglin [2 ]
Xia, Jiahong [3 ]
Tan, Yenong [2 ]
Wang, Xiangdong [1 ]
Zhang, Yuan [3 ]
Zhou, Bing [1 ]
Li, Huabin [1 ]
Han, Demin [1 ]
机构：
[1] Capital Med Univ, Tongren Hosp, Dept Otolaryngol Head & Neck Surg, Beijing, Peoples R China
[2] Hainan Prov Peoples Hosp, Dept Otolaryngol, Haikou, Peoples R China
[3] Huazhong Univ Sci & Technol, Tongji Med Coll, Union Hosp, Dept Surg, Wuhan 430074, Peoples R China
来源：
ACTA OTO-LARYNGOLOGICA | 2009年 / 129卷 / 03期
关键词：
Allergic rhinitis; thymic stromal lymphopoietin; T cell; cytokine; interleukin-4; EPITHELIAL-CELLS; INFLAMMATION;
D O I：
10.1080/00016480802225884
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Conclusion. Thymic stromal lymphopoietin (TSLP) played an important role in the pathogenesis of allergic rhinitis (AR) and can be regarded a potential therapeutic target for the management of AR. Objective. To evaluate the possible role of TSLP in the pathogenesis of AR. Patients and methods. We enrolled 16 patients of AR to investigate the expression of TSLP in nasal mucosa and evaluate the link of TSLP and interleukin-4 (IL-4). Expression of TSLP was detected by immunohistochemical analysis and quantitative reverse transcriptase-polymerase chain reaction (RT-PCR), and concentrations of TSLP and IL-4 were measured by enzyme-linked immunosorbent assay (ELISA). Results. TSLP was detected in all samples and the mRNA and protein expression of TSLP is increased significantly in AR nasal mucosa compared with normal control (P0.05). TSLP production is tightly correlated with IL-4 and severity of AR (P0.05).
引用
收藏
页码：297 / 301
页数：5
相关论文
共 15 条
  • [1] A role for TSLP in the development of inflammation in an asthma model
    Al-Shami, A
    Spolski, R
    Kelly, J
    Keane-Myers, A
    Leonard, WJ
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 202 (06) : 829 - 839
  • [2] Worldwide time trends in the prevalence of symptoms of asthma, allergic rhinoconjunctivitis, and eczema in childhood:: ISAAC Phases One and Three repeat multicountry cross-sectional surveys
    Asher, M. Innes
    Montefort, Stephen
    Bjorksten, Bengt
    Lai, Christopher K. W.
    Strachan, David P.
    Weiland, Stephan K.
    Williams, Hywel
    [J]. LANCET, 2006, 368 (9537) : 733 - 743
  • [3] Allergic rhinitis and its impact on asthma
    Bousquet, J
    van Cauwenberge, P
    Khaltaev, N
    Ait-Khaled, N
    Annesi-Maesano, I
    Bachert, C
    Baena-Cagnani, C
    Bateman, E
    Bonini, S
    Canonica, GW
    Carlsen, KH
    Demoly, P
    Durham, SR
    Enarson, D
    Fokkens, WJ
    van Wijk, RG
    Howarth, P
    Ivanova, NA
    Kemp, JP
    Klossek, JM
    Lockey, RF
    Lund, V
    Mackay, I
    Malling, HJ
    Meltzer, EO
    Mygind, N
    Okunda, M
    Pawankar, R
    Price, D
    Scadding, GK
    Simons, FER
    Szczeklik, A
    Valovirta, E
    Vignola, AM
    Wang, DY
    Warner, JO
    Weiss, KB
    [J]. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2001, 108 (05) : S147 - S334
  • [4] Visual analog scales can assess the severity of rhinitis graded according to ARIA guidelines
    Bousquet, P. J.
    Combescure, C.
    Neukirch, F.
    Klossek, J. M.
    Mechin, H.
    Daures, J. -P.
    Bousquet, J.
    [J]. ALLERGY, 2007, 62 (04) : 367 - 372
  • [5] Thymic stromal lymphopoietin: A potential therapeutic target for allergy and asthma
    Huston, David P.
    Liu, Yong Jun
    [J]. CURRENT ALLERGY AND ASTHMA REPORTS, 2006, 6 (05) : 372 - 376
  • [6] Beyond inflammation: airway epithelial cells are at the interface of innate and adaptive immunity
    Kato, Atsushi
    Schleimer, Robert P.
    [J]. CURRENT OPINION IN IMMUNOLOGY, 2007, 19 (06) : 711 - 720
  • [7] Advances in immunology - Allergy and allergic diseases - First of two parts
    Kay, AB
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (01) : 30 - 37
  • [8] Thymic stromal lymphopoietin: master switch for allergic inflammation
    Liu, YJ
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2006, 203 (02) : 269 - 273
  • [9] Molecular cloning and biological characterization of a novel murine lymphoid growth factor
    Sims, JE
    Williams, DE
    Morrissey, PJ
    Garka, K
    Foxworthe, D
    Price, V
    Friend, SL
    Farr, A
    Bedell, MA
    Jenkins, NA
    Copeland, NG
    Grabstein, K
    Paxton, RJ
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2000, 192 (05) : 671 - 680
  • [10] Changing prevalence of allergic rhinitis and asthma
    Sly, RM
    [J]. ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY, 1999, 82 (03) : 233 - 248
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