Virus-like particles: the future of microbial factories and cell-free systems as platforms for vaccine development

被引：83

作者：

Rodriguez-Limas, William A. ^{[1
]}

Sekar, Karthik ^{[1
]}

Tyo, Keith E. J. ^{[1
]}

机构：

[1] Northwestern Univ, Dept Chem & Biol Engn, Evanston, IL 60208 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2013年 / 24卷 / 06期

基金：

美国国家科学基金会;

关键词：

HUMAN-PAPILLOMAVIRUS; IMMUNE-RESPONSES; DISULFIDE BOND; PROTEIN; DELIVERY; PREVALENCE; EXPRESSION; YEAST; MICE;

D O I：

10.1016/j.copbio.2013.02.008

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Vaccines based on virus-like particles have proved their success in human health. More than 25 years after the approval of the first vaccine based on this technology, the substantial efforts to expand the range of applications and target diseases are beginning to bear fruit. The incursion of high-throughput screening technologies, combined with new developments in protein engineering and chemical coupling, have accelerated the development of systems capable of producing macrostructures useful for vaccinology, gene delivery, immunotherapy and bionanotechnology. This review summarizes the most recent developments in microbial cell factories and cell-free systems for virus-like particle production and discusses the future impact of this technology in human and animal health.

引用

页码：1089 / 1093

页数：5

共 51 条

[1] Chimeric Hepatitis B core antigen virus-like particles displaying the envelope domain III of dengue virus type 2 [J].

Arora, Upasana ;

Tyagi, Poornima ;

Swaminathan, Sathyamangalam ;

Khanna, Navin .

JOURNAL OF NANOBIOTECHNOLOGY, 2012, 10

[2] Cell-Specific Delivery of Diverse Cargos by Bacteriophage MS2 Virus-like Particles [J].

Ashley, Carlee E. ;

Carnes, Eric C. ;

Phillips, Genevieve K. ;

Durfee, Paul N. ;

Buley, Mekensey D. ;

Lino, Christopher A. ;

Padilla, David P. ;

Phillips, Brandy ;

Carter, Mark B. ;

Willman, Cheryl L. ;

Brinker, C. Jeffrey ;

Caldeira, Jerri do Carmo ;

Chackerian, Bryce ;

Wharton, Walker ;

Peabody, David S. .

ACS NANO, 2011, 5 (07) :5729-5745

[3] Heterologous expression of the modified coat protein of Cowpea chlorotic mottle bromovirus results in the assembly of protein cages with altered architectures and function [J].

Brumfield, S ;

Willits, D ;

Tang, L ;

Johnson, JE ;

Douglas, T ;

Young, M .

JOURNAL OF GENERAL VIROLOGY, 2004, 85 :1049-1053

[4] Escherichia coli-based cell-free synthesis of virus-like particles [J].

Bundy, Bradley C. ;

Franciszkowicz, Marc J. ;

Swartz, James R. .

BIOTECHNOLOGY AND BIOENGINEERING, 2008, 100 (01) :28-37

[5] Efficient disulfide bond formation in virus-like particles [J].

Bundy, Bradley C. ;

Swartz, James R. .

JOURNAL OF BIOTECHNOLOGY, 2011, 154 (04) :230-239

[6] Cell-free protein synthesis: Applications come of age [J].

Carlson, Erik D. ;

Gan, Rui ;

Hodgman, C. Eric ;

Jewett, Michael C. .

BIOTECHNOLOGY ADVANCES, 2012, 30 (05) :1185-1194

[7] Chimeric Capsid Protein as a Nanocarrier for siRNA Delivery: Stability and Cellular Uptake of Encapsulated siRNA [J].

Choi, Kyung-mi ;

Choi, Seung-Hye ;

Jeon, Hyesung ;

Kim, In-San ;

Ahn, Hyung Jun .

ACS NANO, 2011, 5 (11) :8690-8699

[8] Clathrin-mediated endocytosis and lysosomal cleavage of hepatitis B virus capsid-like core particles [J].

Cooper, Arik ;

Shaul, Yosef .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2006, 281 (24) :16563-16569

[9] Chimeric calicivirus-like particles elicit specific immune responses in pigs [J].

Crisci, E. ;

Fraile, L. ;

Moreno, N. ;

Blanco, E. ;

Cabezon, R. ;

Costa, C. ;

Mussa, T. ;

Baratelli, M. ;

Martinez-Orellana, P. ;

Ganges, L. ;

Martinez, J. ;

Barcena, J. ;

Montoya, M. .

VACCINE, 2012, 30 (14) :2427-2439

[10] Prevalence and type distribution of human papillomavirus in carcinoma and intraepithelial neoplasia of the vulva, vagina and anus: A meta-analysis [J].

De Vuyst, Hugo ;

Clifford, Gary M. ;

Nascimento, Maria Claudia ;

Madeleine, Margaret M. ;

Franceschi, Silvia .

INTERNATIONAL JOURNAL OF CANCER, 2009, 124 (07) :1626-1636

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