Synthetic studies on the preparation of nucleoside 5′-H-phosphonate monoesters under the Mitsunobu reaction conditions

被引：4

作者：

Laven, Gaston ^{[2
]}

Stawinski, Jacek ^{[1
,2
]}

机构：

[1] Polish Acad Sci, Inst Bioorgan Chem, PL-61704 Poznan, Poland

[2] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden

来源：

ARKIVOC | 2009年

基金：

瑞典研究理事会;

关键词：

H-Phosphonate monoesters; phosphonic acid; the Mitsunobu reaction; ESTERIFICATION REACTION; H-PHOSPHONATES; MECHANISM; TRIPHENYLPHOSPHINE; REAGENTS; AZODICARBOXYLATE; INVOLVEMENT; ACTIVATION; SEPARATION; ESTERS;

D O I：

10.3998/ark.5550190.0010.304

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A reaction of suitably protected nucleosides with phosphonic acid in the presence of diethyl azodicarboxylate and triphenylphosphine in pyridine provided in good yields the corresponding 5'-H-phosphonate monoesters.

引用

页码：20 / +

页数：13

共 40 条

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