Synthetic studies on the preparation of nucleoside 5′-H-phosphonate monoesters under the Mitsunobu reaction conditions

被引：4
作者：
Laven, Gaston [2 ]
Stawinski, Jacek [1 ,2 ]
机构：
[1] Polish Acad Sci, Inst Bioorgan Chem, PL-61704 Poznan, Poland
[2] Stockholm Univ, Arrhenius Lab, Dept Organ Chem, S-10691 Stockholm, Sweden
来源：
ARKIVOC | 2009年
基金：
瑞典研究理事会;
关键词：
H-Phosphonate monoesters; phosphonic acid; the Mitsunobu reaction; ESTERIFICATION REACTION; H-PHOSPHONATES; MECHANISM; TRIPHENYLPHOSPHINE; REAGENTS; AZODICARBOXYLATE; INVOLVEMENT; ACTIVATION; SEPARATION; ESTERS;
D O I：
10.3998/ark.5550190.0010.304
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A reaction of suitably protected nucleosides with phosphonic acid in the presence of diethyl azodicarboxylate and triphenylphosphine in pyridine provided in good yields the corresponding 5'-H-phosphonate monoesters.
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页码：20 / +
页数：13
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