Effects of Acute Exercise and Chronic Exercise on the Liver Leptin-AMPK-ACC Signaling Pathway in Rats with Type 2 Diabetes

被引：31

作者：

Yi, Xuejie ^{[1
,2
]}

Cao, Shicheng ^{[3
]}

Chang, Bo ^{[2
]}

Zhao, Dalin ^{[2
]}

Gao, Haining ^{[2
]}

Wan, Yihan ^{[2
]}

Shi, Jiaojiao ^{[2
]}

Wei, Wei ^{[2
]}

Guan, Yifu ^{[1
]}

机构：

[1] China Med Univ, Coll Basic Med Sci, Dept Biochem & Mol Biol, Shenyang 110001, Peoples R China

[2] Shenyang Sport Univ, Dept Exercise Sci, Shenyang, Peoples R China

[3] China Med Univ, Coll Basic Med Sci, Dept Sport Med, Shenyang 110001, Peoples R China

来源：

JOURNAL OF DIABETES RESEARCH | 2013年 / 2013卷

基金：

中国国家自然科学基金;

关键词：

SKELETAL-MUSCLE; FATTY-LIVER; INSULIN-RESISTANCE; ADIPOSE-TISSUE; PROTEIN-KINASE; POTENTIAL-MECHANISM; ENDURANCE EXERCISE; HEPATIC STEATOSIS; PLASMA LEPTIN; VISCERAL FAT;

D O I：

10.1155/2013/946432

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Aim. To investigate the effects of acute and chronic exercise on glucose and lipid metabolism in liver of rats with type 2 diabetes caused by a high fat diet and low dose streptozotocin (STZ). Methods. Animals were classified into control (CON), diabetes (DC), diabetic chronic exercise (DCE), and diabetic acute exercise (DAE) groups. Results. Compared to CON, the leptin levels in serum and liver and ACC phosphorylation were significantly higher in DC, but the levels of liver leptin receptor, AMPK alpha 1/2, AMPK alpha 1, and ACC proteins expression and phosphorylation were significantly lower in DC. In addition, the levels of liver glycogen reduced significantly, and the levels of TG and FFA increased significantly in DC compared to CON. Compared to DC, the levels of liver AMPK alpha 1/2, AMPK alpha 2, AMPK alpha 1, andACC phosphorylation significantly increased inDCE andDAE. However, significant increase of the level of liver leptin receptor and glycogen aswell as significant decrease of the level of TGand FFAwere observed only inDEC. Conclusion. Our study demonstrated that both acute and chronic exercise indirectly activated the leptin-AMPK-ACC signaling pathway and increased insulin sensitivity in the liver of type 2 diabetic rats. However, only chronic and long- termexercise improved glucose and lipid metabolism of the liver.

引用

页数：9

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