Clinical neurophysiological correlations in migraine

The more accurate definition of the role of cerebral mechanism in migraine development by means of contingent negative deviation (CND) method was the aim of this investigation. The significant alterations of some parameters were revealed In patients with migraine between the fits as compared with controls. The same indices were normal during the very fits. The CND Indices were similar in patients with chronic Headache of strain and healthy individuals. The clinical neurophysiological analysis didn't reveal any significant dependence of CND changes clinical pecullarities and anxious and depressive disorders. The significant elevation of CND parameters observed between the attacks suggests presense of superfluous activity in cerebral structures (noradrenergic mainly) in patients with migraine without aura. Such alterations in their action lead, apparently, to headache attack development.