Effect of Therapeutic Inhibition of TNF on Circulating Endothelial Progenitor Cells in Patients with Rheumatoid Arthritis

被引:51
|
作者
Spinelli, F. R. [1 ]
Metere, A. [2 ]
Barbati, C. [2 ]
Pierdominici, M. [2 ]
Iannuccelli, C. [1 ]
Lucchino, B. [1 ]
Ciciarello, F. [3 ]
Agati, L. [3 ]
Valesini, G.
Di Franco, M. [1 ]
机构
[1] Univ Roma La Sapienza, Dept Internal Med & Med Special, Rheumatol Unit, I-00161 Rome, Italy
[2] Ist Super Sanita, Dept Cell Biol & Neurosci, Sect Biomarkers Degenerat Dis, I-00161 Rome, Italy
[3] Univ Roma La Sapienza, Dept Cardiovasc & Resp Sci, I-00161 Rome, Italy
关键词
TUMOR-NECROSIS-FACTOR; NITRIC-OXIDE SYNTHASE; FACTOR-ALPHA; CARDIOVASCULAR-DISEASE; DYSFUNCTION; ATHEROSCLEROSIS; INFLAMMATION; ASSOCIATION; DEPLETION; NUMBER;
D O I
10.1155/2013/537539
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Endothelial dysfunction has been detected in RA patients and seems to be reversed by control of inflammation. Low circulating endothelial progenitor cells (EPCs) have been described in many conditions associated with increased cardiovascular risk, including RA. The aim of this study was to investigate the effect of inhibition of TNF on EPCs in RA patients. Seventeen patients with moderate-severe RA and 12 sex and age-matched controls were evaluated. Endothelial biomarkers were tested at baseline and after 3 months. EPCs were identified from peripheral blood mononuclear cells by cytofluorimetry using anti-CD34 and anti-vascular endothelial growth factor-receptor 2. Asymmetric dimethylarginine (ADMA) was tested by ELISA and flow-mediated dilatation (FMD) by ultrasonography. Circulating EPCs were significantly lower in RA patients than in controls (P = 0.001). After 3 months EPCs increased significantly (P = 0.0006) while ADMA levels significantly decreased (P = 0.001). An inverse correlation between mean increase in EPCs number and mean decrease of DAS28 after treatment was observed (r = -0.56, P = 0.04). EPCs inversely correlated with ADMA (r = -0.41, P = 0.022). No improvement of FMD was detected. Short-term treatment with anti-TNF was able to increase circulating EPCs concurrently with a proportional decrease of disease activity suggesting that therapeutic intervention aimed at suppressing the inflammatory process might positively affect the endothelial function.
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页数:8
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