Salinomycin: A Novel Anti-Cancer Agent with Known Anti-Coccidial Activities

被引：3

作者：

Zhou, Shuang ^{[1
]}

Wang, Fengfei ^{[1
]}

Wong, Eric T. ^{[2
,3
]}

Fonkem, Ekokobe ^{[4
]}

Hsieh, Tze-Chen ^{[5
]}

Wu, Joseph M. ^{[5
]}

Wu, Erxi ^{[1
]}

机构：

[1] N Dakota State Univ, Dept Pharmaceut Sci, Fargo, ND 58108 USA

[2] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Brain Tumor Ctr, Cambridge, MA 02138 USA

[3] Harvard Univ, Sch Med, Beth Israel Deaconess Med Ctr, Neurooncol Unit, Cambridge, MA 02138 USA

[4] Texas A&M Hlth Sci Ctr, Scott & White Neurosci Inst, Temple, TX USA

[5] New York Med Coll, Dept Biochem & Mol Biol, Valhalla, NY 10595 USA

来源：

CURRENT MEDICINAL CHEMISTRY | 2013年 / 20卷 / 33期

关键词：

Salinomycin; cancer stem cell; toxicity; drug; CANCER STEM-CELLS; EPITHELIAL-MESENCHYMAL TRANSITION; BREAST-CANCER; ION CHANNELS; APOPTOSIS; GROWTH; DRUG; COMBINATION; ERADICATION; RESISTANCE;

D O I：

暂无

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Salinomycin, traditionally used as an anti-coccidial drug, has recently been shown to possess anti-cancer and anti-cancer stem cell (CSC) effects, as well as activities to overcome multi-drug resistance based on studies using human cancer cell lines, xenograft mice, and in case reports involving cancer patients in pilot clinical trials. Therefore, salinomycin may be considered as a promising novel anti-cancer agent despite its largely unknown mechanism of action. This review summarizes the pharmacologic effects of salinomycin and presents possible mechanisms by which salinomycin exerts its anti-tumorigenic activities. Recent advances and potential complications that might limit the utilization of salinomycin as an anti-cancer and anti-CSC agent are also presented and discussed.

引用

页码：4095 / 4101

页数：7

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