How do we optimally use cetuximab in first-line treatment for metastatic colorectal cancer?

被引：0

作者：

Lindsay, Colin R. ^{[1
]}

Roxburgh, Patricia ^{[1
]}

Graham, Janet ^{[1
]}

机构：

[1] Beatson West Scotland Canc Ctr, Glasgow, Lanark, Scotland

来源：

FUTURE ONCOLOGY | 2013年 / 9卷 / 06期

关键词：

cancer; cetuximab; colorectal; irinotecan; oxaliplatin; PHASE-III TRIAL; PLUS IRINOTECAN; CHEMOTHERAPY; FLUOROURACIL; LEUCOVORIN; SURVIVAL; KRAS;

D O I：

10.2217/FON.13.60

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

A number of Phase II/III clinical trials have now been reported assessing the role of cetuximab use in combination with chemotherapy for the first-line treatment of metastatic colorectal cancer. Here we review the current position of cetuximab in this context from two important perspectives. First, we address whether clinicians should prioritize its use with oxaliplatin- or irinotecan-based chemotherapy doublets. Second, we review the trial evidence for the use of cetuximab in patients suffering from colorectal cancer with wild-type and mutant Ras.

引用

页码：825 / 829

页数：5

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