New normal values not related to age and sex, of glomerular filtration rate by 99mTc-DTPA renal dynamic imaging, for the evaluation of living kidney graft donors

The aim of this study was to investigate the normal values of glomerular filtration rate (GFR) by technetium-99m diaethylene triamine pentaacetic acid (Tc-99m-DTPA) renal dynamic imaging for living kidney graft donors. In a total of 212 candidate donors, GFR was examined using Tc-99m-DTPA renal dynamic imaging. Donors with GFR >= 180mL/(min.1.73m(2)) and as low as with GFR >= 70mL/(min.1.73m(2)) but a normal endogenous creatinine clearance rate (CCr) were qualified for living kidney donation. Differences in GFR level based on sex and age were analyzed using rank correlation coefficient. Out of the 212 candidates, 161 were finally selected as kidney graft donors. The double kidney total GFR between the male and female donor groups, the GFR levels among differently-aged donor groups, and the GFR levels between the elderly (>55 years) and young- and middle-aged (<= 55 years) donor groups did not show any significant difference (P>0.05). After kidney donation, renal function measured by blood urea nitrogen (BUN) and serum creatinine of all donors returned to normal within one week, and no serious complications were noticed. In conclusion, renal dynamic imaging by Tc-99m-DTPA had a good accuracy and repeatability in GFR evaluation for living kidney donors. Candidate donors with GFR between 70mL/(min-1.73m(2)) and 80mL/(min.1.73m(2)) can be selected as kidney donors after strict screening. In living kidney donors, GFR is not significantly correlated with age or sex. Hell J Nucl Med 2012; 15(3): 210-214 Epub ahead of print: 26-10-2012 Published on line: 2 December 2012