Endothelin-1 contributes to normocapnic hyperoxic pial artery vasoconstriction

被引：16

作者：

Armstead, WM

机构：

[1] Univ Penn, Dept Anesthesia, Philadelphia, PA 19104 USA

[2] Univ Penn, Dept Pharmacol, Philadelphia, PA 19104 USA

[3] Childrens Hosp Philadelphia, Philadelphia, PA 19104 USA

来源：

BRAIN RESEARCH | 1999年 / 842卷 / 01期

基金：

美国国家卫生研究院;

关键词：

newborn; cerebral circulation; hyperoxia; endothelin;

D O I：

10.1016/S0006-8993(99)01825-9

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The present study was designed to determine if hyperoxia elicits pial artery vasoconstriction and to characterize the contribution of endothelin-1 (ET-1) to that vascular response in newborn pigs equipped with a closed cranial window. Hyperoxic conditions were established by ventilating the piglets with 100% O-2 during normocapnia and concomitantly topically applying artificial CSF that had been bubbled with 100% O-2. Hyperoxia elevated CSF ET-1 from 23 +/- 1 to 45 +/- 4 pg/ml. Hyperoxia also elicited pial artery vasoconstriction that was attenuated by BQ123 (10(-6) M), an ET-1 antagonist (-15 +/- 1 vs. -5 +/- 1%). These data indicate that ET-1 contributes to hyperoxic pial artery vasoconstriction. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：252 / 255

页数：4