Thermochemistry of the dissolution of DL-α-alanyl-DL-norleucine in aqueous solutions of amides at 298.15 K

被引：3

作者：

Smirnov, V. I. ^{[1
]}

Badelin, V. G. ^{[1
]}

机构：

[1] Russian Acad Sci, Krestov Inst Solut Chem, Ivanovo 153045, Russia

来源：

RUSSIAN JOURNAL OF PHYSICAL CHEMISTRY A | 2013年 / 87卷 / 11期

关键词：

peptides; enthalpies of dissolution and transition; water-organic mixtures; enthalpy coefficients of pair interaction; SOLVATOCHROMIC COMPARISON METHOD; ORGANIC SOLVENT MIXTURES; THERMODYNAMIC PROPERTIES; AMINO-ACIDS; PI-STAR; ENTHALPIES; WATER; UREA; ALANINE; SCALE;

D O I：

10.1134/S0036024413110204

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Enthalpies of the dissolution of DL-alpha-alanyl-DL-norleucine are determined by calorimetry in aqueous solutions of formamide (FA), N-methylformamide (MFA), N,N-dimethylformamide (DMF), and N,N-dimethylacetamide (DMA) at a concentration of amides of x (2) = 0-0.4 molar parts and T = 298.15 K. Standard values of enthalpies of dissolution Delta(sol) H (o) and Delta(tr) H (o) of DL-alpha-alanyl-DL-norleucine transfer from water to binary solvent are calculated, along with the enthalpy coefficients of pair interactions h (xy) of DL-alpha-alanyl-DL-norleucine with amide molecules. The effect of the composition of water-organic mixtures and the structure of amides on the enthalpy characteristics of dissolution and transition of DL-alpha-alanyl-DL-norleucine is considered. Quantitative estimates of the contributions to energy from DL-alpha-alanyl-DL-norleucine-amides pair interactions determined by the polarity, polarizability, and electron acceptor and electron donor ability of organic cosolvents are given using the Kamlet-Taft correlation equation.

引用

页码：1793 / 1797

页数：5

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