Synthesis, cytotoxic and antimicrobial activities of novel cobalt and zinc complexes of benzimidazole derivatives

被引：49

作者：

Apohan, Elif ^{[1
]}

Yilmaz, Ulku ^{[2
,3
]}

Yilmaz, Ozgur ^{[4
]}

Serindag, Ayfer ^{[4
]}

Kucukbay, Hasan ^{[3
]}

Yesilada, Ozfer ^{[1
]}

Baran, Yusuf ^{[5
,6
]}

机构：

[1] Inonu Univ, Art & Sci Fac, Dept Biol, Malatya, Turkey

[2] Inonu Univ, Battalgazi Vocat Sch, Battalgazi, Malatya, Turkey

[3] Inonu Univ, Art & Sci Fac, Dept Chem, Malatya, Turkey

[4] Inonu Univ, Inst Sci, Dept Biol, Malatya, Turkey

[5] Izmir Inst Technol, Fac Sci, Dept Mol Biol & Genet, Izmir, Turkey

[6] Abdullah Gul Univ, Fac Life & Nat Sci, Mol Biol & Genet Kayseri, Kayseri, Turkey

来源：

JOURNAL OF ORGANOMETALLIC CHEMISTRY | 2017年 / 828卷

关键词：

Benzimidazole complexes; Cytotoxic; Lung cancer; Antimicrobial; CELL LUNG-CANCER; SUBSTITUTED BENZIMIDAZOLE; STRUCTURAL-CHARACTERIZATION; BIOLOGICAL EVALUATION; METAL-COMPLEXES; IN-VITRO; ANTICANCER; IMIDAZOLE; APOPTOSIS; DESIGN;

D O I：

10.1016/j.jorganchem.2016.11.020

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

In this study fourteen novel cobalt (II) or zinc (II) complexes of benzimidazoles were synthesized from the 1-(4-substitutedbenzyl)-1H-benzimidazoles and CoCl2.6H(2)O or ZnCl2. Cytotoxic activities of novel complexes were investigated against lung cancer cells (A549) and BEAS-2B. Three of the examined compounds (1, 4 and 5) showed high cytotoxic activity against A549. While the IC50 of the cisplatin was 2.56 pg/mL for A549 cells at 72 h, the IC50 values of compounds 1, 4 and 5 were 1.97, 1.87 and 1.9 mu g/mL, respectively. IC50 values of these compounds for BEAS-2B cells were higher than the IC50 values for A549. While the IC50 values for BEAS-2B cells were 59.8, 24.5 and 32.67 mu g/mL, respectively, the IC50 of the cisplatin was determined as 2.53 pgimL in the present work. Three of the compounds have also high antimicrobial activity against all the microorganisms used. (C) 2016 Elsevier B.V. All rights reserved.

引用

页码：52 / 58

页数：7

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