Optimization of continuous-flow diphenyldiazomethane synthesis: an integrated undergraduate chemistry experiment

被引：1

作者：

van Summeren, Luuk T. C. G. ^{[1
]}

Gerretzen, Jan ^{[2
]}

Rutjes, Floris P. J. T. ^{[1
,3
]}

Bloemberg, Tom G. ^{[1
,3
]}

机构：

[1] Radboud Univ Nijmegen, Educ Inst Mol Sci, Heyendaalsweg 135, NL-6525 AJ Nijmegen, Netherlands

[2] Nouryon Chem BV, Integrated Supply Chain Adv Analyt & Control, Zutphenseweg 10, NL-7418 AJ Deventer, Netherlands

[3] Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalsweg 135, NL-6525 AJ Nijmegen, Netherlands

来源：

JOURNAL OF FLOW CHEMISTRY | 2021年 / 11卷 / 01期

关键词：

Diphenyldiazomethane; Chemical education; Flow chemistry; Experimental design; DoE; SULFOXIDE-CARBODIIMIDE REACTIONS; ACID ANHYDRIDE MIXTURES; DIMETHYL-SULFOXIDE; SELECTIVE METHOD; SWERN OXIDATION; DIAZO-COMPOUNDS; ALCOHOLS; CONVERSION; HYDRAZONES; CARBONYLS;

D O I：

10.1007/s41981-020-00107-4

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We present a challenging flow-chemistry experiment concerning the synthesis of diphenyldiazomethane using the Omura-Sharma-Swern oxidation, that we have developed and used in our second-year undergraduate lab classes over the past seven years. The experiment integrates a number of different aspects and concepts of chemistry that are traditionally taught as separate subjects in undergraduate chemical education: organic synthesis, quantitative chemical analysis, design of experiments, optimization, statistical modelling, computer programming and continuous-flow processes.

引用

页码：59 / 66

页数：8

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