Optimization of continuous-flow diphenyldiazomethane synthesis: an integrated undergraduate chemistry experiment

被引：1
作者：
van Summeren, Luuk T. C. G. [1 ]
Gerretzen, Jan [2 ]
Rutjes, Floris P. J. T. [1 ,3 ]
Bloemberg, Tom G. [1 ,3 ]
机构：
[1] Radboud Univ Nijmegen, Educ Inst Mol Sci, Heyendaalsweg 135, NL-6525 AJ Nijmegen, Netherlands
[2] Nouryon Chem BV, Integrated Supply Chain Adv Analyt & Control, Zutphenseweg 10, NL-7418 AJ Deventer, Netherlands
[3] Radboud Univ Nijmegen, Inst Mol & Mat, Heyendaalsweg 135, NL-6525 AJ Nijmegen, Netherlands
来源：
JOURNAL OF FLOW CHEMISTRY | 2021年 / 11卷 / 01期
关键词：
Diphenyldiazomethane; Chemical education; Flow chemistry; Experimental design; DoE; SULFOXIDE-CARBODIIMIDE REACTIONS; ACID ANHYDRIDE MIXTURES; DIMETHYL-SULFOXIDE; SELECTIVE METHOD; SWERN OXIDATION; DIAZO-COMPOUNDS; ALCOHOLS; CONVERSION; HYDRAZONES; CARBONYLS;
D O I：
10.1007/s41981-020-00107-4
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
We present a challenging flow-chemistry experiment concerning the synthesis of diphenyldiazomethane using the Omura-Sharma-Swern oxidation, that we have developed and used in our second-year undergraduate lab classes over the past seven years. The experiment integrates a number of different aspects and concepts of chemistry that are traditionally taught as separate subjects in undergraduate chemical education: organic synthesis, quantitative chemical analysis, design of experiments, optimization, statistical modelling, computer programming and continuous-flow processes.
引用
收藏
页码：59 / 66
页数：8
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