Nox4 as a potential therapeutic target for treatment of uremic toxicity associated to chronic kidney disease

被引：36
作者：
Gorin, Yves [1 ]
机构：
[1] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA
来源：
KIDNEY INTERNATIONAL | 2013年 / 83卷 / 04期
关键词：
INHIBITOR; FIBROSIS; SULFATE;
D O I：
10.1038/ki.2012.434
中图分类号：
R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];
学科分类号：
1002 ; 100201 ;
摘要：
Watanabe et al. report that Nox4 NADPH oxidase catalytic moiety and the subunit p22(phox) mediate the increase in oxidative stress and human tubular epithelial cell injury induced by p-cresyl sulfate, a protein-bound uremic toxin. These findings could be instrumental for the design of novel therapeutic intervention utilizing small-molecule inhibitors specifically targeting Nox oxidases to prevent or slow down the progression of chronic kidney disease and the associated disorders due to uremic toxicity. Kidney International (2013) 83, 541-543. doi:10.1038/ki.2012.434
引用
收藏
页码：541 / 543
页数：3
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