Cryo-EM and single particles

被引：29
作者：
Wang, LG [1 ]
Sigworth, FJ [1 ]
机构：
[1] Yale Univ, Sch Med, Dept Cellular & Mol Physiol, New Haven, CT 06510 USA
来源：
PHYSIOLOGY | 2006年 / 21卷
关键词：
D O I：
10.1152/physiol.00045.2005
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
Cryoelectronmicroscopy is a method for the imaging of macromolecules in the electron microscope. It was originally developed to determine membrane protein structures from two-dimensional crystals, but more recently "single-particle" techniques have become powerful and popular. Three-dimensional reconstructions are obtained from sets of single-particle images by extensive computer processing; the methods are being applied to many macromolecular assemblies.
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页码：13 / 18
页数：6
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