MicroRNA Shuttle from Cell-To-Cell by Exosomes and Its Impact in Cancer

被引：74

作者：

Schwarzenbach, Heidi ^{[1
]}

Gahan, Peter B. ^{[2
]}

机构：

[1] Univ Med Ctr Hamburg Eppendorf, Dept Tumor Biol, D-20246 Hamburg, Germany

[2] Fdn Enrico Puccinelli Onlus, I-06126 Perugia, Italy

来源：

NON-CODING RNA | 2019年 / 5卷 / 01期

关键词：

microRNA biogenesis; microRNA functions; microRNA pathways; exosome biogenesis; exosome functions; exosomal signaling; breast cancer; epithelial; ovarian cancer; prostate cancer; EPITHELIAL OVARIAN-CANCER; BREAST-CANCER; EXTRACELLULAR VESICLES; MEDIATED ENDOCYTOSIS; PROSTATE-CANCER; SMALL RNAS; RESISTANCE; EXPRESSION; MECHANISM; BIOGENESIS;

D O I：

10.3390/ncrna5010028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The identification of exosomes, their link to multivesicular bodies and their potential role as a messenger vehicle between cancer and healthy cells opens up a new approach to the study of intercellular signaling. Furthermore, the fact that their main cargo is likely to be microRNAs (miRNAs) provides the possibility of the transfer of such molecules to control activities in the recipient cells. This review concerns a brief overview of the biogenesis of both exosomes and miRNAs together with the movement of such structures between cells. The possible roles of miRNAs in the development and progression of breast, ovarian and prostate cancers are discussed.

引用

页数：22

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