Suppressing NFAT Increases VEGF Signaling in Hemangiomas

被引：13

作者：

Acevedo, Lisette M. ^{[1
,2
]}

Cheresh, David A. ^{[1
,2
]}

机构：

[1] Univ Calif San Diego, Dept Pathol, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Moores UCSD Canc Ctr, La Jolla, CA 92093 USA

来源：

CANCER CELL | 2008年 / 14卷 / 06期

关键词：

D O I：

10.1016/j.ccr.2008.11.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Infantile hemangiomas represent the most common tumor of endothelial cell (EC) origin, yet the mechanisms regulating hemangioma EC behavior are poorly understood. A new study by Jinnin et al. demonstrates that enhanced VEGFR2 signaling in hemangioma ECs is caused by suppression of NFAT (nuclear factor of activated T cells)-dependent VEGFR1 expression.

引用

页码：429 / 430

页数：2

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