HDACs and HDAC Inhibitors in Cancer Development and Therapy

被引：913

作者：

Li, Yixuan ^{[1
]}

Seto, Edward ^{[1
]}

机构：

[1] George Washington Univ, Ctr Canc, Dept Biochem & Mol Med, Washington, DC 20037 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2016年 / 6卷 / 10期

基金：

美国国家卫生研究院;

关键词：

HISTONE DEACETYLASE INHIBITOR; HUMAN BREAST-CANCER; EPITHELIAL-MESENCHYMAL TRANSITION; HUMAN HEPATOCELLULAR-CARCINOMA; ACUTE MYELOID-LEUKEMIA; RENAL-CELL CARCINOMA; DNA-DAMAGE RESPONSE; PHASE-I; POOR-PROGNOSIS; BIOLOGICAL EVALUATION;

D O I：

10.1101/cshperspect.a026831

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Over the last several decades, it has become clear that epigenetic abnormalities may be one of the hallmarks of cancer. Posttranslational modifications of histones, for example, may play a crucial role in cancer development and progression by modulating gene transcription, chromatin remodeling, and nuclear architecture. Histone acetylation, a well-studied post-translational histone modification, is controlled by the opposing activities of histone acetyl-transferases (HATs) and histone deacetylases (HDACs). By removing acetyl groups, HDACs reverse chromatin acetylation and alter transcription of oncogenes and tumor suppressor genes. In addition, HDACs deacetylate numerous nonhistone cellular substrates that govern a wide array of biological processes including cancer initiation and progression. This review will discuss the role of HDACs in cancer and the therapeutic potential of HDAC inhibitors (HDACi) as emerging drugs in cancer treatment.

引用

页数：34

共 268 条

[61] Histone Deacetylase Inhibitors Equipped with Estrogen Receptor Modulation Activity [J].

Gryder, Berkley E. ;

Rood, Michael K. ;

Johnson, Kenyetta A. ;

Patil, Vishal ;

Raftery, Eric D. ;

Yao, Li-Pan D. ;

Rice, Marcie ;

Azizi, Bahareh ;

Doyle, Donald F. ;

Oyelere, Adegboyega K. .

JOURNAL OF MEDICINAL CHEMISTRY, 2013, 56 (14) :5782-5796

[62] Dual-acting histone deacetylase-topoisomerase I inhibitors [J].

Guerrant, William ;

Patil, Vishal ;

Canzoneri, Joshua C. ;

Yao, Li-Pan ;

Hood, Rebecca ;

Oyelere, Adegboyega K. .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 23 (11) :3283-3287

[63] HDAC inhibitors still need a home run, despite recent approval [J].

Guha, Malini .

NATURE REVIEWS DRUG DISCOVERY, 2015, 14 (04) :226-227

[64] Regulation of STAT3 by histone deacetylase-3 in diffuse large B-cell lymphoma: implications for therapy [J].

Gupta, M. ;

Han, J. J. ;

Stenson, M. ;

Wellik, L. ;

Witzig, T. E. .

LEUKEMIA, 2012, 26 (06) :1356-1364

[65] Selective Activity of the Histone Deacetylase Inhibitor AR-42 against Leukemia Stem Cells: A Novel Potential Strategy in Acute Myelogenous Leukemia [J].

Guzman, Monica L. ;

Yang, Neng ;

Sharma, Krishan K. ;

Balys, Marlene ;

Corbett, Cheryl A. ;

Jordan, Craig T. ;

Becker, Michael W. ;

Steidl, Ulrich ;

Abdel-Wahab, Omar ;

Levine, Ross L. ;

Marcucci, Guido ;

Roboz, Gail J. ;

Hassane, Duane C. .

MOLECULAR CANCER THERAPEUTICS, 2014, 13 (08) :1979-1990

[66] Domain-selective small-molecule inhibitor of histone deacetylase 6 (HDAC6)-mediated tubulin deacetylation [J].

Haggarty, SJ ;

Koeller, KM ;

Wong, JC ;

Grozinger, CM ;

Schreiber, SL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (08) :4389-4394

[67] Cells adapt to the epigenomic disruption caused by histone deacetylase inhibitors through a coordinated, chromatin-mediated transcriptional response [J].

Halsall, John A. ;

Turan, Nil ;

Wiersma, Maaike ;

Turner, Bryan M. .

EPIGENETICS & CHROMATIN, 2015, 8

[68] Type-specific roles of histone deacetylase (HDAC) overexpression in ovarian carcinoma: HDAC1 enhances cell proliferation and HDAC3 stimulates cell migration with downregulation of E-cadherin [J].

Hayashi, Akiko ;

Horiuchi, Akiko ;

Kikuchi, Norihiko ;

Hayashi, Takuma ;

Fuseya, Chiho ;

Suzuki, Akihisa ;

Konishi, Ikuo ;

Shiozawa, Tanri .

INTERNATIONAL JOURNAL OF CANCER, 2010, 127 (06) :1332-1346

[69] Identification of novel isoform-selective inhibitors within class I histone deacetylases [J].

Hu, ED ;

Dul, E ;

Sung, CM ;

Chen, ZX ;

Kirkpatrick, R ;

Zhang, GF ;

Johanson, K ;

Liu, RG ;

Lago, A ;

Hofmann, G ;

Macarron, R ;

de los Frailes, M ;

Perez, P ;

Krawiec, J ;

Winkler, J ;

Jaye, M .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2003, 307 (02) :720-728

[70] Deacetylation of Nuclear LC3 Drives Autophagy Initiation under Starvation [J].

Huang, Rui ;

Xu, Yinfeng ;

Wan, Wei ;

Shou, Xin ;

Qian, Jiali ;

You, Zhiyuan ;

Liu, Bo ;

Chang, Chunmei ;

Zhou, Tianhua ;

Lippincott-Schwartz, Jennifer ;

Liu, Wei .

MOLECULAR CELL, 2015, 57 (03) :456-466

← 2 3 4 5 6 7 8 9 10 11 →